Both retrolinkin and its interaction partner endophilin A1 are required for BDNF-induced dendrite outgrowth of cultured hippocampal neurons. They function sequentially in an early endocytic trafficking pathway for BDNF-activated TrkB, which provides spatiotemporal control of downstream ERK signaling from endosomes.
Retrolinkin, a neuronal membrane protein, interacts with the WAVE1 complex of actin nucleation–promoting factors. Retrolinkin recruits WAVE1 to the plasma membrane to activate Arp2/3-dependent actin polymerization, which is required for BDNF-induced TrkB endocytosis and signaling during dendrite development.
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