Our data suggest that AR may provide another specific definition of breast cancer subtypes and reveal a potential role in DCIS progression. These findings may help develop new therapies.

The methylated status of ASC/TMS1 promoter had the potential applicability for clinical evaluation the prognosis of GC.

These findings reinforce recent suggestions that clonal analysis with AR gene polymerase chain reaction may be used to define the genetic relationships among the human tumor and the breast intraductal proliferative lesions. Furthermore, our observations demonstrate nearly a half ADH and the smaller part of FEA have clonal alterations, which may be neoplastic lesions. This method would shed light on genetic abnormalities that play a role in early tumorigenesis of the breast, and thus might be an adjunct in predicting the probability of breast tumor occurrence and in guiding the management of these cases.

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Volume 32 -Issue S7 -2021 S1445Conclusions: These results above showed this regimen was feasible and tolerable for surgical conversion of stage IV GC pts. Sintilimab, doublet chemotherapy, and apatinib might offer an opportunity of life-prolonging or cure for this population. Trial ID: NCT04267549.

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Overexpression of Skp2 might be the mechanism underlying p27(Kip1) over degradation.