Ropivacaine (RVC), a common pain management drug used for clinical anesthesia and postoperative analgesia, inhibits peripheral nociceptive pain stimulation. However, the potential neurological damage resulting from RVC use must be considered. Developing a strategy to enhance the local
anesthetic effect of RVC while reducing its potential acute toxicity to the central nervous system is urgently needed. In this study, a novel RVC nanocomposite drug, magnetic iron oxide/polyethylene glycol-carboxymethyl chitosan/ropivacaine nanoparticle (mCMCS-PEG/RVC NPs), was synthesized
with magnetic iron oxide. The inherent shell–core structure of mCMCS-PEG retained core magnetic properties, improved the stability and biocompatibility of magnetic nanoparticles, and avoided excessive degradation. Thus, mCMCS-PEG/RVC NPs are expected to provide a new pain management
strategy for perioperative patients.
Purpose: To investigate the effect of dexmedetomidine combined with epidural anesthesia on stress responses and postoperative complications in patients undergoing thoracoscopic radical resection of lung cancer. Methods: A total of 100 patients who underwent radical resection of pulmonary
carcinoma in our hospital between February 2019 and July 2020 were selected and randomly divided into control group (n=50) and experimental group (n=50), and their clinical data were retrospectively analyzed. Among them, the control group patients received epidural anesthesia, while the patients
in the experimental group were treated with dexmedetomidine combined with epidural anesthesia. After that, the anesthesia onset time, duration of analgesia, postoperative waking time, SDSS cognitive function score, VAS pain score, incidence of stress response, postoperative complication rate,
postoperative expression levels of inflammatory factors, as well as blood pressure before surgery (TO), 1 h during surgery (T1), 1 h after surgery (T2), and 2 h after surgery (T3) were compared between the two groups. Results: The anesthesia onset time, SDSS cognitive function score, VAS pain
score, incidence of stress response, postoperative complication rate and postoperative expression levels of inflammatory factors in the experimental group were all significantly lower than those in the control group, with statistical significance (P < 0.05); the duration of analgesia and
postoperative waking time in the experimental group were significantly longer than those in the control group, with statistical significance (P < 0.05); there was no statistical significance in the comparison of the blood pressure at TO, T1, T2 and T3 between the two groups (P > 0.05).
Conclusion:
The application of dexmedetomidine combined with epidural anesthesia for the patients undergoing thoracoscopic radical resection of lung cancer can significantly reduce complication rate after surgery, improve analgesic effect and relieve stress responses in patients.
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