SO is a potentially sight-threatening disease with high rates of visual loss. It warrants prompt evaluation and treatment. With the advances and availability in immunotherapy, the visual prognosis is relatively good.
An implantable glucose microbiosensor that utilizes an electrodeposited redox polymer/glucose oxidase (GOX) sensing membrane and a highly hydrophilic poly (4-vinyl pyridine-co-acrylic acid) (PVP-PAC) overcoating as an analyte-regulating membrane has been developed. A gold microelectrode was electrodeposited with the redox polymer/GOX composite sensing membrane. Two polymers, a hydrophobic poly (4-vinyl pyridine) (PVP) and a hydrophilic PVP-PAC were investigated as possible analyte-regulating membranes. Each was mounted on the sensing layer via chemical cross-linking with poly(ethylene glycol) diglycidyl ether (PEGDGE). High current sensitivities of approximately 220 nA/mM glucose were obtained in the presence of PVP-PAC. In the case of PVP, much lower sensitivities of approximately 30 nA/mM were observed. However, only the biosensor with PVP-PAC showed excellent selectivity to glucose against interferants like oxygen and ascorbic acid (AA). The dynamic range is from 0 to 30 mM. The response time in amperometric measurements was less than 10 sec. Clinical trials showed good correlation between the readings of the subcutaneously implanted biosensor and blood sugar levels.
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