Analysis of 130 Cases of Sympathetic Ophthalmia – A Retrospective Multicenter Case Series

Tan, Xiu Ling; Seen, Sophia; Majumder, Parthopratim Dutta; Ganesh, Sudha K; Agarwal, Mamta; Soni, Aniruddh; Biswas, Jyotirmay; Aggarwal, Kanika; Mahendradas, Padmamalini; Gupta, Vishali; Ling, Ho Su; Teoh, Stephen C.; Pavésio, Carlos; Agrawal, Rupesh

doi:10.1080/09273948.2018.1517894

Cited by 24 publications

(39 citation statements)

References 12 publications

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“…20 Prompt treatment can control SO and maintain good vision in the sympathetic eye. 21 The first patient (Case 1) was treated with pulse methylprednisolone therapy and oral steroids. It should be noted that this patient was intolerant to high doses of steroids because of serious side effects.…”

Section: Discussionmentioning

confidence: 99%

Sympathetic ophthalmia after vitreoretinal surgery: a report of two cases

Shen

Zhang

et al. 2021

J Int Med Res

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Sympathetic ophthalmia (SO) is a panuveitis that usually occurs after trauma to one eye. We describe two cases of SO occurring after 23-gauge vitrectomy. Case 1 involved a 66-year-old woman who underwent pars plana vitrectomy (PPV) for a rhegmatogenous retinal detachment. Two months later, she presented with decreased visual acuity (VA) and bilateral uveitis. Case 2 involved a 43-year-old woman who underwent a second PPV for recurrent retinal detachment. Two months later, she presented with bilateral panuveitis. Both patients were diagnosed with SO and were treated with methylprednisolone and cyclosporine. The first patient was further treated with a dexamethasone intravitreal implant (Ozurdex®) owing to the side effects of methylprednisolone. The VA and symptoms improved significantly after treatment in both patients. Bilateral granulomatous panuveitis following PPV should alert surgeons to consider SO. Appropriate interventions for SO can produce positive outcomes.

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Section: Discussionmentioning

confidence: 99%

Sympathetic ophthalmia after vitreoretinal surgery: a report of two cases

Shen

Zhang

et al. 2021

J Int Med Res

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“… 104 A large multicenter retrospective case series noted that 70.7% of 130 SO patients needed immunosuppressive therapy. 138 …”

Section: Immunomodulatorsmentioning

confidence: 99%

Sympathetic Ophthalmia: Where Do We Currently Stand on Treatment Strategies?

Paulbuddhe¹,

Addya²,

Gurnani³

et al. 2021

OPTH

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“…Americká studie SO z let 1913 -1978 o 105 pacientech, kde převládali muži v 67 %, byla podmíněna především jako pooperační komplikace tehdejších intrakapsulárních extrakcí katarakt v 28 %, přesto v etiologii celkově převládaly penetrující úrazy v 53 %, zároveň SO byla popsána i u těžkých kontuzí oka [51]. V novější indické studii z let přelomu 20. a 21. století bylo zastoupení mužů obdobné v 62 % ze 130 pacientů se SO a její etiologie byla ve ¾ poúrazová [78], což odpovídá pozorování z 80. let minulého století [13]. Souhrnný pohled na české a slovenské studie z let 1958 -2017 uvádí 89 % mužů a 73 % úrazů z 19 sledovaných.…”

Section: Výsledkyunclassified

“…Tuto skutečnost jsme odhalili u jednoho nemocného. Nejčastějšími a inciálními příznaky SO je pokles vidění v 89 % spojený s bolestivostí v 29 % a zákaly ve sklivci v 24 % [78], dále ciliární injekce a fotofobie [76].…”

Section: Výsledkyunclassified

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Long-term Observation of Patients with Sympathetic Ophthalmia from a Diagnostic and Therapeutic Perspective. Overview of Literature

Eckchlager

Smetana

et al. 2019

CSO

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Aim: To evaluate options of diagnostic and therapeutic procedures of sympathetic ophthalmia (SO) compared with literature data. Backgroud: SO is an ocular autoimmune disease. It is characterized by disbalance in the imunoregulatory T-subsets within cell mediated immune response. Methods: File examination of SO by evaluation humoral and cellular immunity was ranked nukleolar test (NT). It evaulates the current status of lymphocyte activation based on the nucleolar morphology and RNA transcription aktivity. The classical histological examination was supported by immunohistochemical analysis of lymphocytic subpopulations in the eyeball enucleated for. SO in one case. Material: Five boys and men overall were monitored and treated in two studies from 1979 to 1994 and from 1999 to 2017 with SO In four cases it was subsequent after penetrating injuries and once after lensectomy with vitrectomy. The age of patients in the time of onset of SO was between 4 and 24 years (average 12 years). The time interval between insult and onset of SO varied between 10 days and 3 months (average 1.7 months). The relaps of disease appeared in the all cases in the time interval from 3 months to 38 years (average 15 years). Another two patients with SO were examined only in consultation: 16 years old boy with relaps of SO after cataract extraction and 71 years old women with SO subsequent after lensectomy and vitrectomy. There was examined and compared group of 19 patients with other types of uveitis in the same time. The lens-associated uveitis were caused after ocular contusion and penetrating eye injury in 16 patients (13 male patients). In another three cases (young women) with uveitid underlined by II. or III. type of hypersenzitivity the enucleation of dolorous eyeball calmed down the secondary uveitis on their second eye without any change of immunosupressive treatment and without change in NT. Results: There were changes in the complex immunological laboratory tests results in the SO cases in the counts of activated lymphocytes in the peripheral blood. The count of activated lymphocytes was increased in SO cases unlike in lens-associated uveitis. There was detected in NT statistically significant difference (p = 0,0134) between the two groups of uveitis. The histological examination (5 eyes with SO and 7 eyes without sympathetic uveitis) confirmed the diagnoses, supporting basically the clinical diagnosis. The immunohistochemical examination corfirmed the presence of populations of T-lymphocytes, macrophages and also B-lymphocytes. A basis of immunosuppressive therapy was the combination of prednisone and azathioprin at the first time. Effective therapy featured cyklosporine later. Conclusion: The nucleolar test of lymphocytes draws attention of their up-to-day increased activity without the diferentiation of subpopulations and their absolute number increase related to the current activation of type IV. hypersensitivity (cell-mediated) in uveitis mechanism. The immunosupressive therapy calmes down this activation predominantly in SO, but also in other case sof uveitis with different types of hypersensivity. The immunohistochemical examination illustrates different presence of lymphocytic types according to the stage of SO.

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Analysis of 130 Cases of Sympathetic Ophthalmia – A Retrospective Multicenter Case Series

Abstract: SO is a potentially sight-threatening disease with high rates of visual loss. It warrants prompt evaluation and treatment. With the advances and availability in immunotherapy, the visual prognosis is relatively good.

Cited by 24 publications

References 12 publications

Sympathetic ophthalmia after vitreoretinal surgery: a report of two cases

Sympathetic ophthalmia after vitreoretinal surgery: a report of two cases

Sympathetic Ophthalmia: Where Do We Currently Stand on Treatment Strategies?

Long-term Observation of Patients with Sympathetic Ophthalmia from a Diagnostic and Therapeutic Perspective. Overview of Literature

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