Monitoring the groundwater storage (GWS) changes is crucial to the rational utilization of groundwater and to ecological restoration in the Loess Plateau of China, which is one of the regions with the most extreme ecological environmental damage in the world. In this region, the mass loss caused by coal mining can reach the level of billions of tons per year. For this reason, in this work, in addition to Gravity Recovery and Climate Experiment (GRACE) satellite gravity data and hydrological models, coal mining data were also used to monitor GWS variation in the Loess Plateau during the period of 2005-2014. The GWS changes results from different GRACE solutions, that is, the spherical harmonics (SH) solutions, mascon solutions, and Slepian solutions (which are the Slepian localization of SH solutions), were compared with in situ GWS changes, obtained from 136 groundwater observation wells, and the aim was to acquire the most robust GWS changes. The results showed that the GWS changes from mascon solutions (mascon-GWS) match best with in situ GWS changes, showing the highest correlation coefficient, lowest root mean square error (RMSE) values and nearest annual trend. Therefore, the Mascon-GWS changes are used for the spatial-temporal analysis of GWS changes. Based on which, the groundwater depletion rate of the Loess Plateau was −0.65 ± 0.07 cm/year from 2005-2014, with a more severe consumption rate occurring in its eastern region, reaching about −1.5 cm/year, which is several times greater than those of the other regions. Furthermore, the precipitation and coal mining data were used for analyzing the causes of the groundwater depletion: the results showed that seasonal changes in groundwater storage are closely related to rainfall, but the groundwater consumption is mainly due to human activities; coal mining in particular plays a major role in the serious groundwater consumption in eastern region of the study area. Our results will help in groundwater resource management, ecological restoration, and policy planning for coal mining and economic development.
Brucella is a typical facultative intracellular bacterium that can cause zoonotic infections. For Brucella, it is difficult to eliminate with current medical treatment. Therefore, a multi-epitope vaccine (MEV) should be designed to prevent Brucella infection. For this purpose, we applied the reverse vaccinology approach from Omp10, Omp25, Omp31 and BtpB. Finally, we obtained 13 cytotoxic T lymphocyte (CTL) epitopes, 17 helper T lymphocyte (HTL) epitopes, 9 linear B cell epitopes, and 2 conformational B cell epitopes for further study. To keep the protein folded normally, we linked AAY, GPGPG, and KK to CTL epitopes, HTL epitopes, and B cell epitopes, respectively. The N-terminal of the vaccine peptide is supplemented with appropriate adjuvants to enhance immunogenicity. To evaluate its immunogenicity, stability, safety, and feasibility, a final MEV containing 806 amino acids was constructed by linking linkers and adjuvants. In addition, molecular docking and molecular dynamics simulations were performed to verify the affinity and stability of the MEV-TLR4. Then, codon adaptation and in silico cloning studies were carried out to identify the possible codons for expressing the MEV. In animal experiments, the results demonstrated that the MEV had high immunogenicity. Collectively, this study provided a theoretical basis for the development of a Brucella vaccine.
Many theoretical and experimental studies have been carried out in order to improve the efficiency and reduce labor for power line inspection, but problems related to stability, efficiency, and comprehensiveness still exist. This paper presents a multiple sensors platform method for overhead power line inspection based on the use of a large unmanned helicopter. Compared with the existing methods, multiple sensors can realize synchronized inspection on all power line components and surrounding objects within one sortie. Flight safety of unmanned helicopter, scheduling of sensors and exact tracking on power line components are very important aspects when using the proposed multiple sensors platform, therefore this paper introduces in detail the planning method for the flight path of the unmanned helicopter and tasks of the sensors before inspecting power lines, and the method used for tracking power lines and insulators automatically during the inspection process. To validate the method, experiments on a transmission line at Qingyuan in Guangdong Province were carried out, the results show that the proposed method is effective for power line inspection.
This study uses the daily maximum and minimum temperature data sets of 48 meteorological stations to assess the observed changes in temperature extremes over China–Pakistan Economic Corridor (CPEC) during 1980–2016. The nonparametric Mann–Kendall, Sen's slope estimator, least squares method, and two‐tailed simple t‐test methods were used to assess the trend in nine temperature extreme indices. The results of the study indicated that the trends in annual mean anomalies of cold nights, cold days, and frost days significantly decreased at the rates of −1.09, −1.58, and −1.05 day/decade, respectively. The number of warm nights, warm days, and summer days exhibited significant positive trends at the rates of 1.49, 1.04, and 4.32 day/decade, respectively. In addition, the trends of the warmest day and coldest day also increased significantly at the rates of 0.45 and 0.51 °C/decade, respectively. The trend of diurnal temperature range decreased significantly with −0.35 °C/decade. The spatial distribution of temperature extreme indices indicated that the number of cold nights, cold days, and diurnal temperature range have been decreased, while the trends of warm nights, warm days, summer days, warmest day, and coldest day have been increased over the whole country. Large‐scale atmospheric circulation changes derived from ERA‐Interim reanalysis show that a weak (strong) wind pressure, increasing (decreasing) geopotential height, and rapid warming (cooling) over the northern (southern) region have contributed to the changes in temperature extremes in Pakistan to some extent. With respect to elevation‐dependent warming (EDW), the trends of cold nights, warm days, summer days, warmest day, and diurnal temperature range showed significant positive correlations with increasing elevation. However, the trends of cold days, warm nights, frost days, and coldest day showed significant negative relationships with increasing elevation. The findings of this study will be helpful in the adaptation of climate change and mitigation of climatological disasters in the region. The study recommends that future studies should investigate the natural and anthropogenic drivers of temperature extremes and the possible mechanism of EDW in the CPEC region.
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