The meibomian gland squeezer may be safe, effective, and helpful for treatment of MGD and may offer an attractive treatment option for some patients with MGD, although it can cause mild pain or discomfort.

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Purpose: To verify the feasibility of using anterior segment optical coherence tomography (AS-OCT) to measure the lower lid margin thickness (LLMT) from posterior lash line to the mucocutaneous junction. Methods: This was a prospective, single-center, observational study. Fifty-six volunteers between 20 and 79 years old with normal healthy eyes were included in this study. Using AS-OCT to measure the LLMT at the middle position was separately performed by two operators under the same conditions. Results: The mean age of 56 subjects (24 males and 32 females) was 45.4 ± 15.7 years. The LLMT measured by AS-OCT between two operators was 0.86 ± 0.23 mm and 0.85 ± 0.22 mm, respectively. The reliability and repeatability between two operators were evaluated by intraclass correlation coefficient (ICC = 0.97). Based on one operator’s measurements, the LLMT was 0.70 ± 0.10 mm at ages 20–29, 0.68 ± 0.09 mm at ages 30–39, 0.94 ± 0.12 mm at ages 40–49, 0.93 ± 0.20 mm at ages 50–59, 1.03 ± 0.15 mm at ages 60–69, and 1.24 ± 0.19 mm at ages 70–79, which indicated a significant positive correlation with age (r_s = 0.74, p < 0.001). In addition, there was a significant difference in the LLMT between genders (0.94 ± 0.26 vs. 0.80 ± 0.19 mm, p = 0.03). Conclusions: A good agreement between two operators indicated that it seemed to be feasible to use AS-OCT to measure the LLMT. Additionally, we found that the LLMT appeared to be closely related to age and gender.

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Complete structural characterization and in vitro antitumor activity of polysaccharides from Zizyphus jujuba cv. Muzao.

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Objectives: To investigate the lower lid margin thickness (LLMT) from the posterior lash line to the anterior edge of tear meniscus with Oculus Keratograph 4 (K4). Methods: This was a prospective, single-center, observational study. A total of 90 volunteers aged 18 to 79 years with no ocular diseases were included in this study. The LLMT of 90 subjects was measured twice by the same person with K4. To determine the reliability of K4, measuring the LLMT of 30 normal subjects was separately performed by two operators. Results: The LLMT measurements with K4 between two operators demonstrated a good reproducibility (0.9460.18 vs. 0.9660.16 mm; intraclass correlation coefficient¼0.88; P¼0.18). The mean age of 90 volunteers (42 men and 48 women) was 45.5614.1 years. The LLMT was 0.9560.17 mm, which was a significant positive correlation with age (r s ¼0.57; P,0.001). In addition, there was no significant difference in the LLMT between genders (0.9760.16 vs. 0.9360.18 mm; P¼0.32). Conclusions: We found that K4 was a reliable tool in the LLMT measurements, and the LLMT seemed to be closely related to age but not to gender.