Background:Ancient medical practitioners used to encourage dietary supplements and herbal medicine for the treatment of type 2 diabetes mellitus (T2DM). Ginger (Zingiber officinale), is a nontoxic spice with negligible side effects, and is considered safe by the food and drug administration. In this analysis, we aimed to systematically compare fasting blood sugar (FBS) and glycated hemoglobin (HbA1c) at baseline versus at follow-up in T2DM patients who consumed and who did not consume ginger.Methods:A literature search was carried out through MEDLINE, Embase, the Cochrane Central, and www.ClinicalTrials.gov for English-published trials comparing glucose parameters in T2DM patients who were assigned to ginger consumption versus a control group. All the participants were patients with T2DM who were either assigned to ginger therapy (1600– 4000 mg daily) or to a control group. FBS and HbA1c were assessed in the ginger and control groups, respectively, from baseline to follow-up to observe any significant change. Weight mean difference (WMD) with 95% confidence intervals (CI) was calculated to represent the analysis which was carried out by the RevMan 5.3 software.Results:Eight randomized trials consisting of a total number of 454 participants with T2DM were included in this analysis. At first, FBS was compared in patients with T2DM from baseline prior to ginger consumption until follow-up after ginger consumption. The results showed no significant difference in FBS (WMD: 1.38, 95% CI: [−0.53–3.30]; P = .16). For the T2DM patients who did not consume ginger, no significant difference in FBS was observed (WMD: −0.27, 95% CI: [−5.09–4.54]; P = .91). However, a significantly improved HbA1c from baseline to follow-up was observed in those participants with ginger consumption (WMD: 0.46, 95% CI: [0.09–0.84]; P = .02) whereas in the control group, no significant difference in HbA1c was observed (WMD: −0.23, 95% CI: [−0.60–0.14]; P = .22).Conclusion:This analysis involving patients with T2DM showed no significant difference in FBS with ginger consumption. However, dietary ginger significantly improved HbA1c from baseline to follow-up showing that this natural medicine might have an impact on glucose control over a longer period of time in patients with T2DM.

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Ileal pouch-anal anastomosis (IPAA) is a classical surgery for ulcerative colitis patients. However, knowledge on trace element alteration in patients who had undergone this surgery is limited. This study was conducted to assess trace element alteration in patients with ulcerative colitis before and after ileal pouch-anal anastomosis. Preoperative (40) and postoperative (35) ulcerative colitis patients were studied. The dietary assessment of trace element intake was undertaken by a semiquantitative food frequency questionnaire. Patients' trace element status of zinc, copper, manganese, selenium, calcium, iron, and vitamin D3 was assessed by measuring their blood concentrations. We found that with the similar dietary intake, there was no statistical difference in the concentrations of plasma copper, iron, calcium, and vitamin D3 in the two groups (P > 0.05). Compared with preoperative patients, postoperative patients had higher concentrations of plasma zinc (14.51 ± 4.75 μmol/l) and manganese (0.21 ± 0.11 μmol/l) and lower concentrations of plasma selenium (0.86 ± 0.58 μmol/l). Both preoperative and postoperative mean concentrations of plasma calcium and vitamin D3 were below their reference range, respectively. We conclude that IPAA does not seem to alter patients' abnormal trace elements completely. It is important to monitor and supply some specified trace elements even in postoperative patients.

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Background The increasing incidence of and adverse events related to refracture among patients with vertebral osteoporotic fractures have attracted increasing attention. In order to carry out preventive strategy effectively, it is of great significance to identify the risk of refractures. In this study, we developed a prediction model to evaluate the risk of refracture after initial fragility fracture.Methods This prospective cohort study was conducted across four tertiary hospitals in Southwest China between April 2018 and December 2021. X-rays were used to diagnose fractures. Participants from 3 of 4 centers were development set and the 4th as a validation set. The discrimination and calibration of each model was assessed using the validation set.Results A total of 1632 patients were included in this study, of which 428 patients suffered a refracture. A total of 11 factors were identified as candidates for predicting refracture were age, rehabilitate, treatment regimen, alcohol consumption, BMI, duration of medication use, history of comorbidities, fall risk, and levels of BGP, TALP, and Hcy. The average AUC of the nomogram was 0.936 (0.92–0.952) in the training set and 0.922 (0.894–0.949) in the validation set. The values for sensitivity, specificity, and accuracy were 0.825, 0.908, and 0.885, respectively.Conclusion We identified 11 independent risk factors that impact refracture risk. These factors were diagramed in a nomogram and transform into online calculator, which can be used to evaluate the risk of refracture among patients with initial vertebral osteoporotic fractures.