As a global and grievous mental disease, major depressive disorder (MDD) has received much attention. Accurate detection of MDD via physiological signals represents an urgent research topic. Here, a frequencydependent multilayer brain network, combined with deep convolutional neural network (CNN), is developed to detect the MDD. Multivariate pseudo Wigner distribution is firstly introduced to extract the time-frequency characteristics from the multi-channel EEG signals. Then multilayer brain network is constructed, with each layer corresponding to a specific frequency band. Such multilayer framework is in line with the nature of the workings of the brain, and can effectively characterize the brain state. Further, a multilayer deep CNN architecture is designed to study the brain network topology features, which is finally used to accurately detect MDD. The experimental results on a publicly available MDD dataset show that the proposed approach is able to detect MDD with state-of-the-art accuracy of 97.27%. Our approach, combining multilayer brain network and deep CNN, enriches the multivariate time series analysis theory and helps to better characterize and recognize the complex brain states.
Electroencephalography-based Brain Computer Interfaces (BCIs) invariably have a degenerate performance due to the considerable individual variability.To address this problem, we develop a novel domain adaptation method with optimal transport and frequency mixup for cross-subject transfer learning in motor imagery BCIs. Specifically, the preprocessed EEG signals from source and target domain are mapped into latent space with an embedding module, where the representation distributions and label distributions across domains have a large discrepancy. We assume that there exists a nonlinear coupling matrix between both domains, which can be utilized to estimate the distance of joint distributions for different domains. Depending on the optimal transport, the Wasserstein distance between source and target domains is minimized, yielding the alignment of joint distributions. Moreover, a new mixup strategy is also introduced to generalize the model, where the inputs trials are mixed in frequency domain rather than in raw space. The extensive experiments on three evaluation benchmarks are conducted to validate the proposed framework. All the results demonstrate that our method achieves a superior performance than previous state-of-the-art domain adaptation approaches.
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