Nanoemulsions
have become extremely popular water-insoluble pesticide
delivery systems in recent years. In this study, prochloraz nanoemulsions
were obtained by selecting the mixing ratio of surfactants (6:1, 3:1,
2:1, 1:1, 1:2, 1:3, and 1:6), surfactant concentration, and shearing
time. The optimal formula was 10 wt % prochloraz, 6 wt % surfactant
(2 wt % CO-100 + 4 wt % CO-360) dissolved in 6 wt % hydrocarbon solvent
(S-100A), and deionized water replenished to 100 wt %. This formula
meets the quality index standards of the Food and Agriculture Organization.
Compared with oil-in-water emulsion (EW), the prochloraz nanoemulsion
exhibited higher antifungal activity against Penicillium
citrinum in vitro (lower LC50 of 1.17 mg
L–1) and in vivo (fewer lesions). In addition, the
L02 cells treated with the nanoemulsion had a higher survival rate
and lower apoptosis rate at the same concentration. Results showed
that the toxicity of the prochloraz nanoemulsion on L02 cells was
lower than that of EW. The findings provide an important method for
developing an efficient, safe, and environment-friendly nanoemulsion
for postharvest fruit storage.
ObjectiveTo evaluate image quality of female pelvic computed tomography (CT) scans reconstructed with the adaptive statistical iterative reconstruction (ASIR) technique combined with low tube-voltage and to explore the feasibility of its clinical application.Materials and MethodsNinety-four patients were divided into two groups. The study group used 100 kVp, and images were reconstructed with 30%, 50%, 70%, and 90% ASIR. The control group used 120 kVp, and images were reconstructed with 30% ASIR. The noise index was 15 for the study group and 11 for the control group. The CT values and noise levels of different tissues were measured. The contrast to noise ratio (CNR) was calculated. A subjective evaluation was carried out by two experienced radiologists. The CT dose index volume (CTDIvol) was recorded.ResultsA 44.7% reduction in CTDIvol was observed in the study group (8.18 ± 3.58 mGy) compared with that in the control group (14.78 ± 6.15 mGy). No significant differences were observed in the tissue noise levels and CNR values between the 70% ASIR group and the control group (p = 0.068-1.000). The subjective scores indicated that visibility of small structures, diagnostic confidence, and the overall image quality score in the 70% ASIR group was the best, and were similar to those in the control group (1.87 vs. 1.79, 1.26 vs. 1.28, and 4.53 vs. 4.57; p = 0.122-0.585). No significant difference in diagnostic accuracy was detected between the study group and the control group (42/47 vs. 43/47, p = 1.000).ConclusionLow tube-voltage combined with automatic tube current modulation and 70% ASIR allowed the low CT radiation dose to be reduced by 44.7% without losing image quality on female pelvic scan.
Background. Many researches revealed that microRNAs (miRNAs) function as potential oncogene or tumor suppressor gene. As an antioncogene, miR-877-5p was reduced in many tumors. Objective. This research aimed to explore the biological role and mechanisms of miR-877-5p, which may help patients with non-small-cell lung cancer (NSCLC) find effective therapeutic targets. Methods. The downstream targets of miR-877-5p were predicted by Bioinformatics software. RT-qPCR and western blot were employed to analyze the gene levels. The impacts of miR-877-5p and FOXM1 were assessed by cell function experiments. Results. The miR-877-5p was reduced in NSCLC. In addition to this, it also inhibited cell progression of NSCLC cells in vitro. Moreover, the upregulation of FOXM1 expression restored the inhibitory effect of enhancement of miR-877-5p. Conclusions. Taken together, miR-877-5p inhibited cell progression by directly targeting FOXM1, which may provide potential biomarkers for targeted therapy of NSCLC.
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