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Hydrogen sulfide (H2S) used to be known as a toxic gas. However, in the last two decades, accumulating evidence has revealed its role as a bioactive molecule in the biological systems. H2S has relatively high expression in the brain, exerting multiple functions in both health and diseases. It modulates neurotransmission by influencing behaviors of NMDA receptors and second messenger systems including intracellular Ca(2+) concentration and intracellular cAMP levels and so forth. H2S shows potential therapeutic value in several CNS diseases including Alzheimer's disease, Parkinson's disease, ischemic stroke, and traumatic brain injury. As a neuroprotectant, H2S produces antioxidant, anti-inflammatory, and antiapoptotic effects in pathological situations. Sulfhydration of target proteins is an important mechanism underlying these effects. This Review summarizes the current understanding of H2S in the central nervous system, with emphasis on its role as a neuromodulator and a neuroprotectant.

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The Heilongjiang Complex is a high-pressure accretionary belt composed mainly of serpentinite, glaucophane-bearing metabasalt, epidote-glaucophanealbite schist, greenschist, marble, two-mica schist, muscovite-albite schist, quartz schist, and quartzite (chert), located along the suture zone separating the Jiamusi and Songliao blocks in NE China. SHRIMP U-Pb zircon analyses of two samples of granitic gneiss from Yilan that are interleaved with the Heilongjiang Complex record diverse protolith ages that are consistent with derivation from regional Permian granitoids (263 ؎ 7 Ma) and the adjacent Mashan Complex (492 ؎ 6 Ma), indicating tectonic incorporation of older granitic components into the accretionary complex. The age of the basaltic protolith of two samples of glaucophane-albite schist from Yilan is ϳ245 Ma and is slightly younger than the protolith age of two samples of amphibole schist from Mudanjiang, located about 200 km south of Yilan, that define weighted mean 206

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