The study aimed to evaluate the diagnostic and prognostic value of indexes detected by electrogastrography (EGG) in Parkinson's disease (PD) patients. 120 early PD patients and 120 healthy controls were recruited, and underwent EGG to detect dominant frequency (DF), instability coefficient of DF (ICDF), low frequency range (LFR), high frequency range (HFR), and normal frequency range (NFR). The receiver operating characteristic (ROC) curve was drawn for the diagnostic value analysis. The motor function was scored with UPDRS. Sniffin' Sticks test was used for the olfactory evaluation, and the TDI score was calculated. The preprandial ICDF of PD patients was significantly higher than that of the control group, and decreased slowly during the late postprandial phase. The levels of LFR%, HFR% and NFR% in PD patients were higher than the control group during both the preprandial and late postprandial phase, and the changes of each index before and after meals were not obvious. Preprandial ICDF value and TDI score had the ability to distinguish PD patients with the AUC of 0.874 and 0.859 respectively. The ICDF detected by EGG has high clinical value in the early diagnosis of PD, and the combination of ICDF and TDI can improve the diagnostic sensitivity and specificity of a single indicator. High ICDF levels during the preprandial phase are related to the poor prognosis of PD patients after treatment.
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