The shape-selective catalysis enabled by zeolite micropore’s molecular-sized sieving is an efficient way to reduce the cost of chemical separation in the chemical industry. Although well studied since its discovery, HZSM-5′s shape-selective capability has never been fully exploited due to the co-existence of its different-sized straight channels and sinusoidal channels, which makes the shape-selective p-xylene production from toluene alkylation with the least m-xylene and o-xylene continue to be one of the few industrial challenges in the chemical industry. Rather than modifications which promote zeolite shape-selectivity at the cost of stability and reactivity loss, here inverse Al zoned HZSM-5 with sinusoidal channels predominantly opened to their external surfaces is constructed to maximize the shape-selectivity of HZSM-5 sinusoidal channels and reach > 99 % p-xylene selectivity, while keeping a very high activity and good stability ( > 220 h) in toluene methylation reactions. The strategy shows good prospects for shape-selective control of molecules with tiny differences in size.

Hydrogen produced from electrocatalytic water splitting is a promising route due to the sustainable powers derived from the solar and wind energy. However, the sluggish kinetics at the anode for water splitting makes the highly effective and inexpensive electrocatalysts desirable in oxygen evolution reaction (OER) by structure and composition modulations. Metal-organic frameworks (MOFs) have been intensively used as the templates/precursors to synthesize complex hollow structures for various energy-related applications. Herein, an effective and facile template-engaged strategy originated from bimetal MOFs is developed to construct hollow microcubes assembled by interconnected nanopolyhedron, consisting of intimately dominant FeNi alloys coupled with a small NiFeO oxide, which was confined within carbonitride outer shell (denoted as FeNi/NiFeO@NC) via one-step annealing treatment. The optimized FeNi/NiFeO@NC exhibits excellent electrocatalytic performances toward OER in alkaline media, showing 10 mA·cm at η = 316 mV, lower Tafel slope (60 mV·dec), and excellent durability without decay after 5000 CV cycles, which also surpasses the IrO catalyst and most of non-noble catalysts in the OER, demonstrating a great perspective. The superior OER performance is ascribed to the hollow interior for fast mass transport, in situ formed strong coupling between FeNi alloys and NiFeO for electron transfer, and the protection of carbonitride layers for long stability.

Replacement of precious platinum with efficient and low-cost catalysts for electrocatalytic hydrogen evolution reaction (HER) at low overpotentials holds tremendous promise for clean energy devices. Herein, molybdenum polysulfide (MoS x ) anchored on a porous Zr-metal organic framework (Zr-MOF, UiO-66-NH 2 ) by chemical interactions is fabricated by a facile and one-pot solvothermal method for HER application. The distinctive design of the Zr-MOF stabilized MoS x composite enables remarkable electrochemical HER activity with a Tafel slope of 59 mV•dec −1 , a lower onset potential of nearly 125 mV, and a cathode current of 10 mA•cm −2 at an overpotential of 200 mV, which also exhibits excellent durability in an acid medium. The superior HER performance should ascribe to the fast electron transport from the less conducting MoS x nanosheets to the electrode, high effective surface area, and number of active sites, as well as the favorable delivery for local protons in the porous Zr-MOF structure during the electrocatalytic reaction. Thus, this work paves a potential pathway for designing efficient Mo-based HER electrocatalysts by the combination of molybdenum polysulfide and versatile proton-conductive MOFs.

(2015) Liposomal co-delivery of daptomycin and clarithromycin at an optimized ratio for treatment of methicillin-resistant Staphylococcusaureus infection, Drug Delivery, 22:5, 627-637, DOI: 10.3109/10717544.2014 CD]) at an optimized mass ratio of 1:32 were generated and characterized using dynamic light scattering and electron microscopy. In vitro and in vivo approaches were used to compare liposome effects on MRSA. Results: PL[CD] were stable, with a mean (±SD) vesicle diameter of 98.2 ± 2.21 nm and encapsulation efficiency of 94.71 ± 1.37% (daptomycin) and 92.94 ± 1.21% (clarithromycin). Compared with daptomycin-only liposomes, PL [CD] showed significantly enhanced anti-MRSA activity in vitro and significantly reduced MRSA bacterial load and increased host survival in vivo. Discussion: Co-delivery of daptomycin with clarithromycin produced significant anti-MRSA activity in the presence of only one-thirtieth of the concentration required in liposomes containing daptomycin only. Conclusion: These findings suggested that concurrent liposomal delivery of daptomycin and clarithromycin has the potential to be an effective and less toxic treatment for MRSA infections.

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