Orbital angular momentum (OAM) of light represents a fundamental optical freedom that can be exploited to manipulate quantum state of atoms. In particular, it can be used to realize spinorbital-angular-momentum (SOAM) coupling in cold atoms by inducing an atomic Raman transition using two laser beams with differing OAM. Rich quantum phases are predicted to exist in manybody systems with SOAM coupling. Their observations in laboratory, however, are often hampered by the limited control of the system parameters. In this work we report, for the first time, the experimental observation of the ground-state quantum phase diagram of the SOAM coupled Bose-Einstein condensate (BEC). The discontinuous variation of the spin polarization as well as the vorticity of the atomic wave function across the phase boundaries provides clear evidence of firstorder phase transitions. Our results open up a new way to the study of phase transitions and exotic quantum phases in quantum gases. arXiv:1806.06263v2 [cond-mat.quant-gas]

Alzheimer’s disease (AD) is a progressive neurodegenerative disease that causes substantial public health care burdens. Intensive efforts have been made to find effective and safe disease-modifying treatment and symptomatic intervention alternatives against AD. Smart Soup (SS), a Chinese medicine formula composed of Rhizoma Acori Tatarinowii (AT), Poria cum Radix Pini (PRP) and Radix Polygalae (RP), is a typical prescription against memory deficits. Here, we assessed the efficacy of SS against AD. Oral administration of SS ameliorated the cognitive impairment of AD transgenic mice, with reduced Aβ levels, retarded Aβ amyloidosis and reduced Aβ-induced gliosis and neuronal loss in the brains of AD mice. Consistently, SS treatment reduced amyloid-related locomotor dysfunctions and premature death of AD transgenic Drosophila. Mechanistic studies showed that RP reduced Aβ generation, whereas AT and PRP exerted neuroprotective effects against Aβ. Taken together, our study indicates that SS could be effective against AD, providing a practical therapeutic strategy against the disease.

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Attaching a piezoelectric transducer to a vibrating structure, and shunting it with an electric circuit, gives rise to different passive, semi-passive, and semi-active control techniques. This paper attempts to review the research related to structural vibration control, via passive, semi-passive, and semi-active control methods. First, the existing electromechanical modeling is reviewed, along with the modeling methods. These range from lumped parameters, to distributed parameters modeling of piezostructural systems shunted by electrical networks. Vibration control laws are then discussed, covering passive, semi-passive, and semi-active control techniques, which are classified according to whether external power is supplied to the piezoelectric transducers, or not. Emphasis is placed on recent articles covering semi-passive and semi-active control techniques, based upon switched shunt circuits. This review provides the necessary background material for researchers interested in the growing field of vibration damping and control, via shunted piezostructural systems.

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Alzheimer's disease (AD) is a common neurodegenerative disease affecting cognitive function in the elderly, which is characterized by the presence of extracellular deposits of insoluble amyloid-β plaques and neuronal loss. Modern pharmacology and drug development usually follow a single-target principle, which might contribute to the failure of most compounds in clinical trials against AD. Considering AD is a multifactorial disease, a combination therapeutic strategy that applies drugs with different mechanisms would be an alternative way. Smart Soup (SS), a Traditional Chinese Medicine formula, is composed of three herbaceous plants and has been applied in the treatment of amnesia in China for hundreds of years. In this work, we studied the clinical potency of the combination of SS and Aricept in AD therapy. In the in vivo model, both longevity and locomotive activity of AD transgenic Drosophila were improved remarkably in the combined medicine treated group. We also observed less amyloid-β deposition and retarded neuronal loss following the combined drug treatment. In the retrospective cohort study, we found the combination therapy exerted better therapeutic effect on AD patients. Our study revealed that combination therapy with multiple drug targets did have a better therapeutic outcome. It provides a new strategy to develop an optimum pharmaceutical approach against AD.

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