Dendroside A (1) and dendronobilosides A and B (2 and 3), three new sesquiterpene glycosides, have been isolated from the stems of Dendrobium nobile, a plant used in Chinese traditional medicine. Their structures and stereochemistry were determined as 10beta,12,14-trihydroxyalloaromadendrane 14-O-beta-D-glucopyranoside (1), 10,12-dihydroxypicrotoxane 10,12-di-O-beta-D-glucopyranoside (2), and 6alpha,10,12-trihydroxypicrotoxane 10-O-beta-D-glucopyranoside (3), respectively, on the basis of spectroscopic and chemical methods. Quantum chemistry calculations were used in support of the structural determination of 1. Compounds 1 and 2 were found to stimulate the proliferation of murine T and B lymphocytes in vitro, while compound 3 showed inhibitory activity in this same assay.
Two new triterpenoid saponins, biondianosides F and G, together with 13 known compounds, were isolated from the ethanolic extract of the roots of Biondiachinensis Schltr. (Asclepiadaceae). Their structures were characterized as 3-O-beta-D-glucopyranosyl-2alpha,3beta-dihydroxyurs-12-en-28-oic acid-beta-D-glucopyranosyl-(1-->2)-[beta-D-glucopyranosyl-(1-->6)]-beta-D-glucopyranosyl ester (biondianoside F) and 3-O-beta-D-glucopyranosyl-2alpha,3beta,23-trihydroxyolean-12-en-28-oic acid-beta-D-glucopyranosyl-(1-->2)-beta-D-glucopyranosyl ester (biondianoside G) by spectral and chemical evidence.
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