Transition-metal-catalyzed asymmetric fluoroalkylation remains a challenging topic due to the lack of efficient enantioselective catalysts to facilitate the catalytic cycle with fluoroalkylating reagents. In this article, Zhang and co-workers report a copper-catalyzed highly enantioselective difluoroalkylation of secondary propargyl sulfonates using difluoroenoxysilanes. The combination of copper with PyBox shows a highly catalytic effect for the enantioselective synthesis of propargylic a,a-difluoroketones that can serve as versatile building blocks for diverse transformations.
A nickel-catalyzed
carbonylative difluoroalkylation reaction with
arylboronic acids under 1 atm of CO has been developed. The reaction
proceeds under mild reaction conditions with high efficiency and high
functional group tolerance. Preliminary mechanistic studies reveal
that the arylacyl nickel complex is the key intermediate to circumvent
the formation of labile fluoroacyl nickel, and bimetallic oxidative
addition is likely the key step to facilitate the catalytic cycle.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.