An unprecedented highly stereoselective example of nickel-catalyzed Suzuki-Miyaura type cross-coupling reactions of (2,2-difluorovinyl)benzene derivatives with arylboronic acids was developed. The reaction proceeded efficiently in the presence of 5 mol% NiCl2(PCy3)2 and K3PO4, affording the Z-fluorostyrene derivatives in good to high yields with excellent regioselectivity.
A practical and convenient approach for the secondary C(sp(3))-H arylation of diarylmethanes with various fluoroarenes is described. The reaction proceeds smoothly in the presence of LDA (lithium diisopropylamide) at room temperature and affords triarylmethanes in moderate to high yields.
A copper-free direct C−H ortho trifluoromethylation of electron-deficient 4-substituted acetanilides using Langlois reagent (NaSO 2 CF 3 ) as the CF 3 source in the presence of tert-butyl hydroperoxide (tBuOOH, TBHP) was developed.
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