The application of geopolymer adhesive to CFRP-strengthened the RC structure is a new green reinforcement method, and the bonding behavior of geopolymer adhesive was studied in this paper. The geopolymer mechanical properties orthogonal test was conducted and the optimal proportion was obtained, which summarized the influence of slag powder content, liquid-solid ratio, and water glass modulus. A total of 15 adhesively bonded CFRP-concrete double-lap joints were fabricated and tested under shear loading to investigate the effect of geopolymer adhesive on the bonding behaviors. Modified bondslip models of the geopolymer adhesive specimens were developed and compared with the test date. The results showed that the failure models of epoxy adhesive and geopolymer adhesive are different. The bond strength, interface stiffness, and maximum shear stress of the geopolymer adhesive specimen can reach 93.6% ~97.6%, 95.7% ~132.9%, and 91% ~94% of the bond strength of epoxy adhesive respectively. The predicted τ max and s 0 of the proposed model are in excellent agreement with the experimental data, and the maximum deviation is À9.58%. This study proposes that geopolymer could be applied as an effective adhesive in the strengthening of RC structures.
BackgroundDysregulated non-coding RNAs exhibit critical functions in various cancers. Nonetheless, the levels and corresponding functions of cirCSNX14 in esophageal squamous cell carcinoma (ESCC) yet remain to be elucidated.MethodsInitially, the aberrant low levels of lncRNA-LET within ESCC tissues are validated via qRT-PCR observations. Moreover, the effects of lncRNA-LET upregulation on cell proliferation in vitro are determined. In addition, a series of assays determining the mechanistic views related to metabolism is conducted. Furthermore, the effects of lncRNA-LET in affecting tumor growth are investigated in vivo in a mouse model. Moreover, the interactions between lncRNA-LET and its networks are predicted and determined by RNA immunoprecipitation-assisted qRT-PCR as well as luciferase reporter assays.ResultsThe downregulation of lncRNA-LET is correlated to the poor prognosis of ESCC patients. Moreover, the upregulated expression of lncRNA-LET could have reduced the cell viability. In vivo tumor inhibition efficacy assays showed that an increase of lncRNA-LET presented excellent inhibitory effects on cancer proliferation as reflected by tumor weight and volume in mice. Finally, the mechanistic views regarding the effects of miR-106b-5p or miR-93-5p and SOCS4 on ESCC are related to the feedback of lncRNA-LET.ConclusionCollectively, this study suggested that lncRNA-LET miR-93-5p or the miR-106b-5p–SOCS4 axis may provide great potential in establishing ESCC therapy.
PurposeThe effects of carbon fiber reinforced polymer (CFRP) reinforcement form, adhesive type and pre-crack width on failure mode, shear capacity, deflection response, CFRP strain response and crack patterns of strengthened specimens were investigated.Design/methodology/approachThis paper presents a geopolymer adhesive that matches the performance requirements of CFRP adhesive, which is applied to pre-cracked beams reinforced with CFRP strips. FindingsFor specimens with varying structural properties, two failure modes, the CFRP-concrete interface substrate failure and the fracture failure of CFRP, are observed. Moreover, the shear capacity, ultimate deflection and bending stiffness of the U-shaped CFRP-strengthened beams are enhanced in comparison to the complete-wrapping CFRP-strengthened beams. With an increase in pre-crack width, the increase in shear capacity of RC beams shear-strengthened with CFRP strips is less than that of non-cracked beams, resulting in a limited influence on the stiffness of CFRP-strengthened beams. The comparison of experimental results showed that the proposed finite element model (FEM) effectively evaluated the mechanical characteristics of CFRP-strengthened RC beams.Originality/valueTaking into consideration the reinforcement effect and the concept of environmental protection, the geopolymer adhesive reinforcement scheme is preferable to applying epoxy resin to the CFRP-strengthened RC beams.
Background: In multiple malignant tumors, circular RNAs (circRNAs) are believed to play a crucial role. Our prior results demonstrated that circ_ZNF778_006 was significantly increased in esophageal squamous cell carcinoma(ESCC) tissues, but the roles of circ_ZNF778_006 in ESCC is still not clear. Methods:The expression of circ_ZNF778_006 was compared in different pathological grades of ESCC. And the expression levels of circ_ZNF778_006, miR-18b-5p, HIF-1α were analyzed by qRT-PCR and Western blot, respectively. Plasmid transfection techniques were applied to prepare ESCC cells with silenced or overexpressed genes (CircZNF778_006, miR-18b-5p). The CCK8 kit was used to determine cell proliferation, and the Transwell assay was used to measure the migration and invasion. The effects of circ_ZNF778_006 on tumor growth was investigated in vivo. Furthermore, luciferase reporter gene assay and RNA-binding protein immunoprecipitation(RIP) were performed to verify the targeting relationship between miR-18b-5p and circZNF778_006, miR-18b-5p and HIF-1α. Results: The expression of circ_ZNF778_006 was positively correlated with pathological grade in ESCC. Circ_ZNF778_006 significantly inhibited sensitivity to 5-fluorouracil & cisplatin. It could promote the proliferation, invasion, migration in ESCC cells and accelerated tumor growth in vivo. Furthermore, circ_ZNF778_006 could upregulate the expression of HIF-1α via sponing miR-18b-5p. Conclusion: Circ_ZNF778_006 promoted ESCC progression by upregulating HIF-1α expression via sponging miR-18b-5p.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.
hi@scite.ai
10624 S. Eastern Ave., Ste. A-614
Henderson, NV 89052, USA
Copyright © 2024 scite LLC. All rights reserved.
Made with 💙 for researchers
Part of the Research Solutions Family.