The present study deals with the functional interaction of antipsychotic drugs and NMDA receptors. We show that both the conventional antipsychotic drug haloperidol and the atypical antipsychotic drug clozapine mediate gene expression via intracellular regulation of NMDA receptors, albeit to different extents. Data obtained in primary striatal culture demonstrate that the intraneuronal signal transduction pathway activated by haloperidol, the cAMP pathway, leads to phosphorylation of the NR1 subtype of the NMDA receptor at (897)Ser. Haloperidol treatment is likewise shown to increase (897)Ser-NR1 phosphorylation in rats in vivo. Mutation of (896)Ser and (897)Ser to alanine, which prevents phosphorylation at both sites, inhibits cAMP-mediated gene expression. We conclude that antipsychotic drugs have the ability to modulate NMDA receptor function by an intraneuronal signal transduction mechanism. This facilitation of NMDA activity is necessary for antipsychotic drug-mediated gene expression and may contribute to the therapeutic benefits as well as side effects of antipsychotic drug treatment.
The dynamics force of iced-conductor is the driving force of galloping, its variation is depended on the aerodynamic character of iced conductor. The aerodynamic character of iced conductor is the key factor of galloping of iced-conductor, but the result of theoretically analysis and numerical simulation isn’t suited for the requirement of transmission line project. In the paper, basing on the theoretically analysis and numerical simulation, the simulation tests in wind tunnel of crescent-shaped iced conductor is stetted up and put into practice, and then the systemic study is carried into execution. The result of research is indicated that there is a better coherence between the numerical simulation and experiment test, and the result of numerical simulation is the beneficial supplement to the experiment test. The result can not only provide the original date for the galloping analysis, but also validate the affectivity of numerical simulation, support the research of mechanism and control of galloping.
Accounting for the disastrous phenomena of ice-accreted conductor galloping, wind tunnel tests of LGJ630/45 conductor accreted with crescent-shaped ice are conducted. Based on the test results, conductor galloping is simulated by employing the PCL language of ANSYS commercial software package and then the influences of span lengths as well as free-stream speeds on galloping characteristics are studied. The results indicate that, conductor galloping consists several different frequency components. With the increase of span length, galloping energy moves from low-frequency component to its high-frequency counterpart, and finally high-frequency component dominates the galloping phenomenon. And with the movement of energy, galloping traces transforms from ellipse to that similar to a butterfly. With the increase of span length, the maximum cable tension first increases, next decreases sharply, and then increases again.
For conductors commonly used in the high and ultra-high voltage transmission projects, research was conducted on how ice shape, ice thickness, wind speed and angle of attack affect the static aerodynamic characteristics of ice-coated conductor. The ice shape and the shape of ice-coated conductor are both important factors that determine the aerodynamic characteristics of conductor. Sudden increase of lift coefficient may happen at low angle of attack. Wind speed shows less effect on aerodynamic characteristics of ice-coated conductor with streamlined shape than that of conductor with blunt shape. Under most attack angles, aerodynamic coefficients increase as the ice thickness increases. The aerodynamic load on ice-coated conductor does not increase linearly with the diameter of conductor.
The dynamics force of iced-conductor is the driving force of galloping; its variation is depended on the aerodynamic character of iced conductor. The aerodynamic character of iced conductor is the key factor of galloping of iced-conductor, but the result of theoretically analysis and numerical simulation isn’t suited for the requirement of transmission line project. In the paper, basing on the theoretically analysis and numerical simulation, the simulation tests in wind tunnel of D-shaped iced conductor is stetted up and put into practice under different wind speed and iced thickness, and then the systemic study is carried into execution. The result of research is indicated that there is a better coherence between the numerical simulation and experiment test, and the variation rules of parameters is obvious with the different iced thickness, the result of numerical simulation is the beneficial supplement to the experiment test. The result can not only provide the original date for the galloping analysis, but also validate the affectivity of numerical simulation, support the research of mechanism and control of galloping.
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