Coronal mass ejections (CMEs) and solar flares are the large-scale and most energetic eruptive phenomena in our solar system and able to release a large quantity of plasma and magnetic flux from the solar atmosphere into the solar wind. When these highspeed magnetized plasmas along with the energetic particles arrive at the Earth, they may interact with the magnetosphere and ionosphere, and seriously affect the safety of human high-tech activities in outer space. The travel time of a CME to 1 AU is about 1-3 days, while energetic particles from the eruptions arrive even earlier. An efficient forecast of these phenomena therefore requires a clear detection of CMEs/flares at the stage as early as possible. To estimate the possibility of an eruption leading to a CME/flare, we need to elucidate some fundamental but elusive processes including in particular the origin and structures of CMEs/flares. Understanding these processes can not only improve the prediction of the occurrence of CMEs/flares and their effects on geospace and the heliosphere but also help understand the mass ejections and flares on other solar-type stars. The main purpose of this review is to address the origin and early structures of CMEs/flares, from multi-wavelength observational perspective. First of all, we start with the ongoing debate of whether the pre-eruptive configuration, i.e., a helical magnetic flux rope (MFR), of CMEs/flares exists before the eruption and then emphatically introduce observational manifestations of the MFR. Secondly, we elaborate on the possible formation mechanisms of the MFR through distinct ways. Thirdly, we discuss the initiation of the MFR and associated dynamics during its evolution toward the CME/flare. Finally, we come to some conclusions and put forward some prospects in the future.

The topology and dynamics of the three-dimensional magnetic field in the solar atmosphere govern various solar eruptive phenomena and activities, such as flares, coronal mass ejections, and filaments/prominences. We have to observe and model the vector magnetic field to understand the structures and physical mechanisms of these solar activities. Vector magnetic fields on the photosphere are routinely observed via the polarized light, and inferred with the inversion of Stokes profiles. To analyze these vector magnetic fields, we need first to remove the 180 • ambiguity of the transverse components and correct the projection effect. Then, the vector magnetic field can be served as the boundary conditions for a force-free field modeling after a proper preprocessing. The photospheric velocity field can also be derived from a time sequence of vector magnetic fields. Three-dimensional magnetic field could be derived and studied with theoretical force-free field models, numerical nonlinear force-free field models, magnetohydrostatic models, and magnetohydrodynamic models. Magnetic energy can be computed with three-dimensional magnetic field models or a time series of vector magnetic field. The magnetic topology is analyzed by pinpointing the positions of magnetic null points, bald patches, and quasi-separatrix layers. As a well conserved physical quantity, magnetic helicity can be computed with various methods, such as the finite volume method, discrete flux tube method, and helicity flux integration method. This quantity serves as a promising parameter characterizing the activity level of solar active regions.

To investigate the factors that control the success and/or failure of solar eruptions, we study the magnetic field and 3-Dimensional (3D) configuration of 16 filament eruptions during 2010 July -2013 February. All these events, i.e., erupted but failed to be ejected to become a coronal mass ejection (CME), are failed eruptions with the filament maximum height exceeding 100M m. The magnetic field of filament source regions is approximated by a potential field extrapolation method. The filament 3D configuration is reconstructed from three vantage points by the observations of STEREO Ahead/Behind and SDO spacecraft. We calculate the decay index at the apex of these failed filaments and find that in 7 cases, their apex decay indexes exceed the theoretical threshold (n crit = 1.5) of the torus instability. We further determine the orientation change or rotation angle of each filament top during the eruption. Finally, the distribution of these events in the parameter space of rotation angle versus decay index is established. Four distinct regimes in the parameter space are empirically identified. We find that, all the torus-unstable cases (decay index n > 1.5), have a large rotation angles ranging from 50 • − 130 • . The possible mechanisms leading to the rotation and failed eruption are discussed. These results imply that, besides the torus instability, the rotation motion during the eruption may also play a significant role in solar eruptions.

Solar flares typically have an impulsive phase that followed by a gradual phase as best seen in soft X-ray emissions. A recent discovery based on the EUV Variability Experiment (EVE) observations onboard the Solar Dynamics Observatory (SDO) reveals that some flares exhibit a second large peak separated from the first main phase peak by tens of minutes to hours, which is coined as the flare's EUV late phase (Woods et al. 2011). In this paper, we address the origin of the EUV late phase by analyzing in detail two late phase flares, an M2.9 flare on 2010 October 16 and an M1.4 flare on 2011 February 18, using multipassband imaging observations from the Atmospheric Imaing Assembly (AIA) onboard SDO. We find that: (1) the late phase emission originates from a different magnetic loop system, which is much larger and higher than the main phase loop system. (2) The two loop systems have different thermal evolution. While the late phase loop arcade reaches its peak brightness progressively at a later time spanning for more than one hour from high to low temperatures, the main phase loop arcade reaches its peak brightness at almost the same time (within several minutes) in all temperatures. (3) Nevertheless, the two loop systems seem to be connected magnetically, forming an asymmetric magnetic quadruple configuration. (4) Further, the footpoint brightenings in UV wavelengths show a systematic delay of about one minute from the main flare region to the remote footpoint of the late phase arcade system. We argue that the EUV late phase is the result of a long-lasting cooling process in the larger magnetic arcade system.

SummaryHepatocyte-like cells (HLCs) can be generated through directed differentiation or transdifferentiation. Employing two strategies, we generated induced pluripotent stem cell (iPSC)-HLCs and hiHeps from the same donor cell line. Both types of HLCs clustered distinctly from each other during gene expression profiling. In particular, differences existed in gene expression for phase II drug metabolism and lipid accumulation, underpinned by H3K27 acetylation status in iPSC-HLCs and hiHeps. While distinct phenotypes were achieved in vitro, both types of HLCs demonstrated similar phenotypes following transplantation into Fah-deficient mice. In conclusion, functional HLCs can be obtained from the same donor using two strategies. Global gene expression defined the differences between those populations in vitro. Importantly, both HLCs displayed partial but markedly improved hepatic function following transplantation in vivo, demonstrating plasticity and the potential for cell-based modeling in the dish and cell-based therapy in the future.

Summary Coronal mass ejections (CMEs) are large-scale explosions of the coronal magnetic field. It is believed that magnetic reconnection significantly builds up the core structure of CMEs, a magnetic flux rope, during the eruption. However, the quantitative evolution of the flux rope, particularly its toroidal flux, is still unclear. In this paper, we study the evolution of the toroidal flux of the CME flux rope for four events. The toroidal flux is estimated as the magnetic flux in the footpoint region of the flux rope, which is identified by a method that simultaneously takes the coronal dimming and the hook of the flare ribbon into account. We find that the toroidal flux of the CME flux rope for all four events shows a two-phase evolution: a rapid increasing phase followed by a decreasing phase. We further compare the evolution of the toroidal flux with that of the Geostationary Operational Environmental Satellites soft X-ray flux and find that they are basically synchronous in time, except that the peak of the former is somewhat delayed. The results suggest that the toroidal flux of the CME flux rope may be first quickly built up by the reconnection mainly taking place in the sheared overlying field and then reduced by the reconnection among the twisted field lines within the flux rope, as enlightened by a recent 3D magnetohydrodynamic simulation of CMEs.

Coronal mass ejections (CMEs) often exhibit the classic three-part structure in a coronagraph, i.e., the bright front, dark cavity, and bright core, which are traditionally considered as the manifestations of coronal plasma pileup, magnetic flux rope (MFR), and filament, respectively. However, a recent survey based on 42 CMEs all possessing the three-part structure found that a large majority (69%) do not contain an eruptive filament at the Sun. Therefore, a challenging opinion is proposed and claims that the bright core can also correspond to the MFR, which is supported by the CME simulation. Then what is the nature of the CME core? In this paper, we address this issue through a CME associated with the eruption of a filament-hosting MFR on 2013 September 29. This CME exhibits the three-part morphology in multiple white-light coronagraphs from different perspectives. The new finding is that the bright core contains both a sharp and a fuzzy component. Through tracking the filament motion continuously from its source region to the outer corona, we conclude that the sharp component corresponds to the filament. The fuzzy component is suggested to result from the MFR that supports the filament against the gravity in the corona. Our study can shed more light on the nature of CME cores, and explain the core whether or not the filament is involved with a uniform scenario. The nature of the CME cavity is also discussed.

Coronal mass ejections (CMEs) are frequently associated with filament eruptions. Theoretical studies propose that both magnetic reconnection and ideal magnetohydrodynamic instability of magnetic flux ropes can convert coronal magnetic energy into the filament/CME kinetic energy. Numerical simulations and analytical considerations demonstrate that both mechanisms can have significant contributions to the filament/CME acceleration. Many observational studies support that reconnection plays an important role during the acceleration, while it remains open how to resolve observationally the contribution of the ideal instability to the acceleration. On the other hand, it is difficult to separate and compare their contributions through observations as both mechanisms often work in a close time sequence. In this Letter, the above issues are addressed by analyzing the eruption process of a quiescent filament. The filament started to rise from ∼00:00 UT on 2011 December 25, 20 minutes earlier than the starting time of the flare impulsive phase (∼00:20 UT), and reached the maximum velocity at the flare peak time (∼00:50 UT). We divide the acceleration process into two stages, corresponding to the pre-flare and flare impulsive phases, respectively. The analysis indicates that an ideal flux-rope instability is dominant in the first stage, while reconnection below the flux rope becomes important during the second stage, and both mechanisms may have comparable contributions to the net acceleration of the filament.