To support the global restart of elective surgery, data from an international prospective cohort study of 8492 patients (69 countries) was analysed using artificial intelligence (machine learning techniques) to develop a predictive score for mortality in surgical patients with SARS-CoV-2. We found that patient rather than operation factors were the best predictors and used these to create the COVIDsurg Mortality Score (https://covidsurgrisk.app). Our data demonstrates that it is safe to restart a wide range of surgical services for selected patients.
Glioblastoma (GBM) is the most aggressive and common primary tumor of the central nervous system. It is characterized by having an infiltrating growth and by the presence of an excessive and aberrant vasculature. Some of the mechanisms that promote this neovascularization are angiogenesis and the transdifferentiation of tumor cells into endothelial cells or pericytes. In all these processes, the release of extracellular microvesicles by tumor cells plays an important role. Tumor cell-derived extracellular microvesicles contain pro-angiogenic molecules such as VEGF, which promote the formation of blood vessels and the recruitment of pericytes that reinforce these structures. The present study summarizes and discusses recent data from different investigations suggesting that Netrin-1, a highly versatile protein recently postulated as a non-canonical angiogenic ligand, could participate in the promotion of neovascularization processes in GBM. The relevance of determining the angiogenic signaling pathways associated with the interaction of Netrin-1 with its receptors is posed. Furthermore, we speculate that this molecule could form part of the microvesicles that favor abnormal tumor vasculature. Based on the studies presented, this review proposes Netrin-1 as a novel biomarker for GBM progression and vascularization.
In Chile, the brown alga Macrocystis pyrifera has been subject to strong harvesting pressure, resulting in severe reduction of natural beds, and a threat to the sustainability of the resource. Repopulation is a possible means for the recovery of overexploited natural populations of M. pyrifera. In this study, we determined density (ind. cm-2), length (mm) and biomass (g) of M. pyrifera sporophytes sown on three types of substrata (ceramic plates, pot scrubbers, clam shells). In laboratory experiments, sporophytes on ceramic plates were significantly longer than those on pot scrubbers or shells after 60 days, and their density was also higher. Juvenile sporophytes seeded on the three substrata were transferred to the sea and placed either inside or outside a M. pyrifera forest. At the end of the experiment in the sea under the kelp forest, highest biomass and length were obtained on the clam shell substrates, but the density did not show significant differences between the substrates. However, outside the kelp forest, no significant differences in kelp density or length were observed between the three substrates tested; but the biomass was significantly higher on the clam shells than on the other two substrata. We conclude that the installation of kelp seeded substratum units may be an option for recovery of exploited M. pyrifera forests.
INTRODUCTION: Following the recent explosion of academic interest within the field of global surgery, this study aimed to identify the financial barriers researchers from low-and middle-income countries (LMICs) face in order to access and publish global surgical research. METHODS:A comprehensive review of scientific publications from January 2010-December 2019 pertaining to global surgery in LMICs was conducted using the Scopus Ò database. Journals with three or more publications during this period were included and data relating to journal accessibility, publication-associated costs, and availability of financial support for LMIC authors were obtained.
En los tiempos que corren, donde la motivación de muchos escritores es la simple búsqueda del impacto de venta, Flavia busca hablar de lo que tiene cercano, interpretando en tono de ficción policiaca las historias de la gente que conoce, lo que lee, lo que escucha, lo que ve con esa mirada curiosa y creativa, tomando como punto neurálgico la ciudad en la que se radicó, Granada...
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