Objective: To determine the risk factors of infection in patients with nephrotic syndrome. Methods: A retrospective study was conducted on 155 patients with nephrotic syndrome under our department from January 2019 to December 2019. Among them, 43 cases had infection, and the rate of infection was 27.74%. The risk factors of infection were analyzed. Results: Among the 155 patients with nephrotic syndrome, 43 cases developed infection, including 3 cases of upper respiratory tract infection (6.98%), 33 cases of lower respiratory tract infection (76.74%), 3 cases of skin infection (6.97%), 3 cases of urinary tract infection (6.97%), and 1 case of facial nerve infection (2.32%). Compared with the group without infection, the group with infection had lower serum albumin and immunoglobulin G (IgG) levels as well as higher serum creatinine and 24-hour urinary protein levels (P < 0.05). Multivariate logistic regression analysis showed that decreased serum albumin (odds ratio [OR] = 1.14; P < 0.01) and IgG (OR = 1.1; P < 0.144) were independent risk factors for infection. Conclusion: Respiratory infection is the most common infection in nephrotic syndrome, and the decrease in serum albumin and IgG are independent risk factors for infection.
Objective: To further evaluate the efficacy and safety of low-dose glucocorticoids combined with tacrolimus in the treatment of adult idiopathic membranous nephropathy (IMN) in a clinical setting. Methods: We carried out a single-center prospective study of 88 patients with IMN who were admitted into the Affiliated Hospital of Hebei University from January 2019 to December 2021, and the participants were divided into two groups based on their serum anti-PLA2R antibody levels: the negative group and the positive group. 46 patients were positive for anti-PLA2R antibodies and 42 were negative. Results: After 6 months of treatment, the serum albumin, cholesterol, and 24h urine protein quantification in the anti-PLA2R negative group improved more significantly compared to the positive group (P < 0.05); after 6 months of treatment, the remission rate of the positive group was significantly lower than that of the negative group, and (P < 0.05); Conclusion: After treatment with tacrolimus combined with low-dose glucocorticoids, patients with idiopathic membranous nephropathy who were tested positive for anti-PLA2R antibodies had a higher overall remission rate compared those who were tested negative for serum anti-PLA2R antibodies.
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