We describe a novel missense mutation (Aspartic acid to Asparagine, p.D419N (g.1371G>A, c.1255G>A) within exon 9 of SH3BP2 in a patient with cherubism, an autosomal dominant syndrome characterized by excessive osteoclastic bone resorption of the jaw. Two siblings and the father were carriers but lacked phenotypic features. Transient expression of p.D419N (c.1255G>A), as well as three previously described exon 9 mutations from cherubism patients (p.R415Q (c.1244G>A), p.D420E (c.1259G>A), and p.P418R (c.1253C>G)) increased activity of NFAT (nuclear factor of activated T-cells), an osteoclastogenic mediator, indicating that cherubism results from gain of function mutations in SH3BP2.
In this paper, by using bilinear form and extended three-wave type of ansätz approach, we obtain new multi-soliton solutions of the (3+1)-dimensional Jimbo-Miwa equation, including the periodic breather-type of kink three-soliton solutions, the cross-kink four-soliton solutions, the doubly periodic breather-type of soliton solutions and the doubly periodic breather-type of cross-kink two-soliton solutions. It is shown that the generalized three-wave method, with the help of symbolic computation, provides an effective and powerful mathematical tool for solving high dimensional nonlinear evolution equations in mathematical physics.
Diversity soliton solutions, including breather-type kink two wave solutions, cross-kink two solitary solutions, breather-type kink three wave solutions, kink three soliton solutions, are obtained for the (2+1)-Dimensional Boiti-Leon-Manna-Pempinelli Equation by using Hirota's bilinear form and extended homoclinic test approach, respectively. Moreover, the properties for some new solutions are shown with some figures.
In this work, (2+1)-dimensional Bogoyavlenskii-Schiff equation, which cann't be converted to a complete form of Hirota's bilinear operator, is considered. By using modification of extended homoclinic test approach new kink breather soliton and kink multi-solitons solutions are obtained and exhibited, respectively.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.