Sulfoximines, a ubiquitous class of structural motifs, are widely present in bioactive molecules and functional materials that have received considerable attention from modern organic chemistry, pharmaceutical industries, and materials science. Sulfoximines have proved to be an effective directing group for C–H functionalization which was widely investigated for the synthesis of cyclic sulfoximines. Within the last decade, great progress has been achieved in the synthesis of cyclic sulfoximines. Thus, this review highlights the recent advances in the synthesis of cyclic sulfoximines via the C–H activation strategy and is classified based on the substrate types.
A new class of Corey−Chaykovsky reagent type fivemembered heterocycles with an oxosulfonium ylide moiety has been synthesized by the water-mediated intramolecular cyclization/ oxidation of α-carbonyl sulfur ylides generated in situ from sulfonium salts under mild conditions. S ulfur ylides, discovered by Johnson by accident, 1 were defined as zwitterionic compounds consisting of a carbonion and neighboring sulfur cations, which are easily prepared from their sulfonium salts (R 2 S + -CHR 2 •X − ) under basic conditions. Later, the Corey−Chaykovsky reagent derived from dimethyl sulfoxide was discovered in 1962. 2 It often produces the corresponding three-membered-ring products by the addition of a carbon−carbon or carbon− heteroatom double bond (such as ketones, aldehydes, imines and α,β-unsaturated carbonyl compounds) (Scheme 1), which
Chiral sulfones, a class of organic compounds with broad application prospects in organic synthesis and pharmaceutical chemistry, are an important part of building bioactive molecules or functional materials. In this paper, the advances and the state of synthesizing chiral sulfones by addition reactions are reviewed. The methods described in the manuscript are classified according to the types of reaction. Moreover, each chapter is arranged in chronological order.
Enantiomerically enriched five‐ and six‐membered benzo oxygen heterocycles are privileged architectures in functional organic molecules. Over the last several years, many effective methods have been established to access these compounds. However, comprehensive documents cover updated methodologies still in highly demand. In this review, recent transition metal catalyzed transformations lead to chiral five‐ and six‐membered benzo oxygen heterocycles are presented. The mechanism and chirality transfer or control processes are also discussed in details.
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