Narrative story generation is a challenging problem because it demands the generated sentences with tight semantic connections, which has not been well studied by most existing generative models. To address this problem, we propose a skeleton-based model to promote the coherence of generated stories. Different from traditional models that generate a complete sentence at a stroke, the proposed model first generates the most critical phrases, called skeleton, and then expands the skeleton to a complete and fluent sentence. The skeleton is not manually defined, but learned by a reinforcement learning method. Compared to the state-of-the-art models, our skeleton-based model can generate significantly more coherent text according to human evaluation and automatic evaluation. The G-score is improved by 20.1% in human evaluation. 1
SummaryYin Yang 1 (YY1) regulates early embryogenesis and adult tissue formation. However, the role of YY1 in stem cell regulation remains unclear. YY1 has a Polycomb group (PcG) protein-dependent role in mammalian cells. The PcG-independent functions of YY1 are also reported, although their underlying mechanism is still undefined. This paper reports the role of YY1 and BAF complex in the OCT4-mediated pluripotency network in mouse embryonic stem cells (mESCs). The interaction between YY1 and BAF complex promotes mESC proliferation and pluripotency. Knockdown of Yy1 or Smarca4, the core component of the BAF complex, downregulates pluripotency markers and upregulates several differentiation markers. Moreover, YY1 enriches at both promoter and super-enhancer regions to stimulate transcription. Thus, this study elucidates the role of YY1 in regulating pluripotency through its interaction with OCT4 and the BAF complex and the role of BAF complex in integrating YY1 into the core pluripotency network.
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