Aim: To screen clinical and genetic risk factors and examine their combined effect on docetaxel, epirubicin and cyclophosphamide (TEC) regimen-induced liver injury (TEC-ILI). Patients & methods: We enrolled 396 breast cancer patients, and TEC-ILI-associated factors were screened by logistic regression analyses. Results: SOD2 rs4880 and ABCG2 rs2231142 polymorphisms correlated with an increased risk of TEC-ILI. Multivariate analysis incorporating clinical and genetic factors revealed that ABCC1 rs246221 (CC) and SOD2 rs4880 (AG/GG) increased the risk of TEC-ILI. Patients with at least two risk factors among nonalcoholic fatty liver disease, high low-density lipoproteinemia levels and the rs246221 or rs4880 adverse genotypes exhibited a significantly increased risk of developing TEC-ILI. Conclusion: The combination of clinical and genetic risk factors had higher predictive value for TEC-ILI than the interclinical risk factors alone.
According to the existing personnel structure, quantity, development strategy, and market demand of the Shuohuang Railway Company’s operation and maintenance project, the demand quantity of various employees of the company for the past three years is predicted, and a human resource optimization model based on existing human resources and future plans is established. Then, the optimal solutions of the two mathematical models were calculated and analyzed using LINGO software. Finally, combined with the actual situation, the optimal allocation of human resources for the operation and maintenance project of KY company was obtained. The following conclusions are obtained. (1) For the optimal allocation model of existing human resources, the maximum net profit of the optimal staffing model is CNY 3258000. (2) The human resources allocation cost of the minimum dismissal model is CNY 81000. (3) The human resources allocation cost of the lowest cost model is CNY 15500. The research results can effectively guide the human resource management of the operation and maintenance project of the Shuohuang Railway Company, and have important theoretical and practical significance for further analysis of human resources model and its optimal allocation method.
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