SummaryCDKA;1 is required for the termial divison of stomatal development. The results presented here use targeted expression to fine-tune the roles of CDKs and cyclins in regulating guard cell production.
The rice genome contains a single gene OsCYCA2;1 encoding A2-type cyclin, which is an evolutionarily conserved protein required for asymmetric cell divisions to produce stomatal lineage cells.
Genetic studies based on single-nucleotide polymorphisms have provided valuable insights into the genetic architecture of complex diseases. However, a large fraction of heritability for most of these diseases remains unexplained, and the impact of small insertions and deletions (InDels) has been neglected. We performed a comprehensive screen on the exome sequence data of 1,326 genes using the SOAP-PopIndel method for InDels in 32,043 Chinese Han individuals and identified 29 unreported InDels within 25 susceptibility genes associated with psoriasis. Specifically, we identified 12 common, 9 low-frequency, and 8 rare InDels that explained approximately 1.29% of the heritability of psoriasis. Further analyses identified KIAA0319,
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