Experimental measurements in deep-inelastic scattering and lepton-pair production on deuterium targets play an important role in the flavor separation of u and d (anti)quarks in global QCD analyses of the parton distribution functions (PDFs) of the nucleon. We investigate the impact of theoretical corrections accounting for the light-nuclear structure of the deuteron upon the fitted u, d-quark, gluon, and other PDFs in the CJ15 and CT18 families of next-to-leading order CTEQ global analyses. The investigation is done using the $$L_2$$
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sensitivity statistical method, which provides a common metric to quantify the strength of experimental constraints on various PDFs and ratios of PDFs in the two distinct fitting frameworks. Using the $$L_2$$
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sensitivity and other approaches, we examine the compatibility of deuteron data sets with other fitted experiments under varied implementations of the deuteron corrections. We find that freely-fitted deuteron corrections modify the PDF uncertainty at large momentum fractions and will be relevant for future PDFs affecting electroweak precision measurements.
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