An N-heterocyclic carbene (NHC) catalyzed asymmetric [3 + 3] annulation of α-bromoenals with 5-aminopyrazoles is described. Using the established methodology, a structurally diverse set of high value dihydropyrazolo[3,4-b]pyridine-6ones were efficiently constructed in high yields (up to 99%) with excellent enantioselectivities (up to > 99%). The easily available starting materials, broad substrate scope, mild reaction conditions, excellent yield and enantioselectivity make this strategy attractive for the asymmetric construction of pyrazolo-fused pyridone derivatives.
A novel N-heterocyclic carbene (NHC)-catalyzed asymmetric [3+3] cycloaddition between α-bromoenals and 5-aminoisoxazoles has been developed. With this method, various dihydroisoxazolo[5,4-b]pyridin-6-ones were obtained in high yields (up to 99%) with excellent...
An efficient N-heterocyclic carbene (NHC)-catalyzed [3 + 3] cycloaddition of α-bromoenals with β-nitro enamines has been developed. This methodology provides an efficient strategy for the construction of valuable nitro-containing heterocyclics....
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