A catalyst and additive-free annulation of 2pyridylacetates and ynals under molecular oxygen was the first developed, affording 3-acylated indolizines in good to excellent yields. Molecular oxygen was used as the source of the carbonyl oxygen atom in indolizines. This approach was compatible with a wide range of functional groups, and especially it has been successfully extended to unsaturated double bonds and triple bonds, which were difficult to prepare by previous methods in a single step.
An efficient synthesis of a variety of pyridyl benzamides from 2-aminopyridines and nitroolefins is described. This rare-earth-metal-catalyzed reaction provides the corresponding products with broad substrate scope in moderate to excellent yields, in the absence of additives and external oxidants. Water is used as the source of the carbonyl oxygen atom in pyridyl benzamides. Furthermore, 2-substituted oxazolo[4,5-b]pyridines are formed in good yields under the standard conditions when 2-aminopyridin-3-ols are used as the substrates.
Cu-catalyzed domino decyanation and
cyanation reaction of acyl
cyanides with amines or alcohols have been developed. The cyano sources
were generated in situ via C–CN cleavage yielding the corresponding
cyano substituted amides or esters in moderate to excellent yields.
This approach features a cheap copper catalyst, domino decyanation
and cyanation reaction, readily available starting materials, broad
substrate scope, operational simplicity, and the potential for further
transformation of the cyano group.
An efficient nano-Cu2O-catalyzed cascade multicomponent reaction of 2-halobenzoic acids and trimethylsilyl cyanide with diverse amines was developed using water as solvent, affording versatile N-substituted phthalimide derivatives in moderate to excellent...
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