In the process of bone regeneration, new bone formation is largely affected by physico-chemical cues in the surrounding microenvironment. Tissue cells reside in a complex scaffold physiological microenvironment. The scaffold should provide certain circumstance full of structural cues to enhance multipotent mesenchymal stem cell (MSC) differentiation, osteoblast growth, extracellular matrix (ECM) deposition, and subsequent new bone formation. This article reviewed advances in fabrication technology that enable the creation of biomaterials with well-defined pore structure and surface topography, which can be sensed by host tissue cells (esp., stem cells) and subsequently determine cell fates during differentiation. Three important cues, including scaffold pore structure (i.e., porosity and pore size), grain size, and surface topography were studied. These findings improve our understanding of how the mechanism scaffold microenvironmental cues guide bone tissue regeneration.

A note on versions:The version presented here may differ from the published version or from the version of record. If you wish to cite this item you are advised to consult the publisher's version. Please see the repository url above for details on accessing the published version and note that access may require a subscription. Understanding how quantum resources can be quantified and distributed over many parties has profound applications in quantum communication. As one of the most intriguing features of quantum mechanics, Einstein-Podolsky-Rosen (EPR) steering is a useful resource for secure quantum networks. By reconstructing the covariance matrix of a continuous variable four-mode square Gaussian cluster state subject to asymmetric loss, we quantify the amount of bipartite steering with a variable number of modes per party, and verify recently introduced monogamy relations for Gaussian steerability, which establish quantitative constraints on the security of information shared among different parties. We observe a very rich structure for the steering distribution, and demonstrate one-way EPR steering of the cluster state under Gaussian measurements, as well as one-to-multimode steering. Our experiment paves the way for exploiting EPR steering in Gaussian cluster states as a valuable resource for multiparty quantum information tasks.

Measurement-based one-way quantum computation using cluster states as resources provides an efficient model to perform computation and information processing of quantum codes. Arbitrary Gaussian quantum computation can be implemented sufficiently by long single-mode and two-mode gate sequences. However, continuous variable gate sequences have not been realized so far due to an absence of cluster states larger than four submodes. Here we present the first continuous variable gate sequence consisting of a single-mode squeezing gate and a two-mode controlled-phase gate based on a six-mode cluster state. The quantum property of this gate sequence is confirmed by the fidelities and the quantum entanglement of two output modes, which depend on both the squeezing and controlled-phase gates. The experiment demonstrates the feasibility of implementing Gaussian quantum computation by means of accessible gate sequences.

The deployment of a cylinder based on origami with Kresling pattern, whose basic mechanisms are formed by the buckling of a thin cylindrical shell under torsional loading, is studied in this paper. The model consists of identical triangular panels with cyclic symmetry and has a small displacement internal inextensional mechanism. First, geometric formulation of the design problem is presented. Then, assuming that the deployment and folding process is uniform, the bistable behavior of the cylinder is discussed. It can be found that, during the deployment, the dimensionless strain energy increases first and then reduces to zero but followed by another sharp increase. Moreover, the limit condition of geometry parameters for the bistable phenomenon is also discussed. Finally, the bistable behavior is also studied by using numerical simulations for simple and more complex case of the cylinder with multistory. The numerical results agree well with the analytical predictions. Therefore, comparisons with finite element predictions have shown that the analytical solutions given in this paper are accurate and have validated the assumptions made in the derivations.

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SUMMARYIn this paper, we target more advanced fluid-structure interaction (FSI) simulations of wind turbines than reported previously. For this, we illustrate how the recent advances in isogeometric analysis of thin structures may be used for efficient structural mechanics modeling of full wind turbine structures, including tower, nacelle, and blades. We consider both horizontal axis and vertical axis wind turbine designs. We enhance the sliding-interface formulation of aerodynamics, previously developed to handle flows about mechanical components in relative motion such as rotor-tower interaction to allow nonstationary sliding interfaces. To accommodate the nonstationary sliding interfaces, we propose a new mesh moving technique and present its mathematical formulation. The numerical examples include structural mechanics verification for the new offshore wind turbine blade design, FSI simulation of a horizontal axis wind turbine undergoing yawing motion as it turns into the wind and FSI simulation of a vertical axis wind turbine. The FSI simulations are performed at full scale and using realistic wind conditions and rotor speeds.

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