A multifunctional
nanoplatform based on mesoporous silica nanoparticles
(MSNs) was developed for combinational tumor therapy. Doxorubicin
(DOX) was chosen as an antitumor drug and loaded into mesopores of
MSNs via physical absorption. Then, a tumor-targeted fusion peptide
conjugated with 2,3-dimethylmaleic anhydride (DTCPP) and a therapeutic
peptide conjugated with 2,3-dimethylmaleic anhydride (DTPP) were introduced
to the surface of MSNs as super-pH-sensitive nanovalves through disulfide
linkages. The BSA adsorption assay confirmed the charge-reversal property
of MSN-ss-DTPP&DTCPP nanoparticles at slightly acidic condition
(pH 6.8) and superior stability in physiological environment (pH 7.4).
According to the drug release research, both glutathione (GSH) and
acidic condition are required for the accelerated drug release from
DOX@MSN-ss-DTPP&DTCPP nanoparticles. Moreover, in vitro studies
demonstrated the significantly reinforced tumor cellular uptake efficiency
and mitochondrial disruption ability of DOX@MSN-ss-DTPP&DTCPP
nanoparticles in tumor environment, in which DOX@MSN-ss-DTPP&DTCPP
nanoparticles exhibited the preferred cytotoxicity toward αvβ3-positive human cervical carcinoma (HeLa)
cells. We believe that the multifunctional dual-stimuli-sensitive
MSN could provide an effective strategy for combinational tumor therapy.
Surface photografting with 2-hydroxyethyl methacrylate phosphate has been used to improve the flame retardancy of polyamide 6.6 fabrics. Limiting oxygen index tests and vertical burning tests were used to characterize the fire performance. The highest limiting oxygen index value of the grafted sample can reach up to 31.2, which is 58% higher than that of the ungrafted fabric. The thermal stability and char morphology of the polyamide 6.6 fabrics have been characterized by the thermogravimetric analysis and scanning electron microscopy analysis. Kinetic analysis on fabric samples was investigated, and the results show that the activation energy of the grafted sample is higher than that of the ungrafted fabric.
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