The high performance photodetector based on CsPb(Br/I)3-NC/CdS-MW heterostructures showed broadband photodetection that covers UV-VIS-NIR range due to the charge transfer at the heterojunction interface and the absorption capability of CsPb(Br/I)3.
In the saline water area of our research, deep groundwater was over-pumped for agricultural irrigation which resulted in a decline of the deep groundwater level and an increase in the shallow groundwater table. Soil salination was also aggravated due to the strong evapotranspiration (ET) in the shallow groundwater areas, where ET removes water vapor from the unsaturated zone (ETu), and the groundwater (ETg). Joint utilities of multiple water sources of transferred water and local shallow and deep groundwater are essential for reasonable management of irrigation water. However, it is still difficult to distinguish ETu and ETg in coupled management of unsaturated zone and groundwater, which account for the water balance in utilities of multiple water sources in a regional scale. In this paper, we used an RS-based ETWatch model as a source of evapotranspiration data coupled with UZF-MODFLOW, an integrated hydrological model of the unsaturated–saturated zone, to estimate the ETg and ETu on a regional scale. It was shown that the coupled model (ETWatch-UZF-MODFLOW) avoids the influence of ETu on the groundwater balance calculation and improves the accuracy of the groundwater model. The model was used in the simulation and prediction of groundwater level. The eastern North China Plain (NCP) was selected as the study area where shallow groundwater was saline water and deep groundwater cone existed. We compared four different scenarios of irrigation methods, including current irrigation scenario, use of saline water, limited deep groundwater pumping, use of multiple water sources of transferred water and local groundwater. Results indicate that the total ETg for the four scenarios in the study area from 2013 to 2030 is 119 × 108 m3, 81.9 × 108 m3, 85.0 × 108 m3, and 92.3 × 108 m3, respectively, and the proportion of ETg to total ET was 6.85%, 4.79%, 4.97%, 5.37%. However, in regions where the groundwater depth is less than 3 m, ETg accounts for 12% of the total ET, indicating that groundwater was one of the main sources of evapotranspiration in shallow groundwater depth area.
Background: An imbalance of redox homeostasis participates in tumorigenesis, proliferation, and metastasis, which results from the production of reactive oxygen species (ROS). However, the biological mechanism and prognostic significance of redox-associated messenger RNAs (ramRNAs) in lung adenocarcinoma (LUAD) still remain unclear.Methods: Transcriptional profiles and clinicopathological information were retrieved from The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) of LUAD patients. A total of 31 overlapped ramRNAs were determined, and patients were separated into three subtypes by unsupervised consensus clustering. Biological functions and tumor immune-infiltrating levels were analyzed, and then, differentially expressed genes (DEGs) were identified. The TCGA cohort was divided into a training set and an internal validation set at a ratio of 6:4. Least absolute shrinkage and selection operator regression were used to compute the risk score and determine the risk cutoff in the training set. Both TCGA and GEO cohort were distinguished into a high-risk or low-risk group at the median cutoff, and then, relationships of mutation characteristics, tumor stemness, immune differences, and drug sensitivity were investigated.Results: Five optimal signatures (ANLN, HLA-DQA1, RHOV, TLR2, and TYMS) were selected. Patients in the high-risk group had poorer prognosis, higher tumor mutational burden, overexpression of PD-L1, and lower immune dysfunction and exclusion score compared with the low-risk group. Cisplatin, docetaxel, and gemcitabine had significantly lower IC50 in the high-risk group.Conclusion: This study constructed a novel predictive signature of LUAD based on redox-associated genes. Risk score based on ramRNAs served as a promising biomarker for prognosis, TME, and anti-cancer therapies of LUAD.
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