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In this paper, we revisit the quantum Fisher information (QFI) calculation in SU(1,1) interferometer considering different phase configurations. When one of the input modes is a vacuum state, we show by using phase averaging, different phase configurations give same QFI. In addition, by casting the phase estimation as a two-parameter estimation problem, we show that the calculation of the quantum Fisher information matrix (QFIM) is necessary in general. Particularly, within this setup, the phase averaging method is equivalent to a two parameter estimation problem. We also calculate the phase sensitivity for different input states using QFIM approach. arXiv:1810.08242v1 [quant-ph]

Expanded newborn screening facilitates early identification and intervention of patients with inborn errors of metabolism (IEMs), There is a lack of disease spectrum data for many areas in China. To determine the disease spectrum and genetic characteristics of IEMs in Xi'an city of Shaanxi province in northwest China, 146152 newborns were screening by MSMS from January 2014 to December 2019 and 61 patients were referred to genetic analysis by next generation sequencing (NGS) and validated by Sanger sequencing. Seventy-five newborns and two mothers were diagnosed with IEMs, with an overall incidence of 1:1898 (1:1949 without mothers). There were 35 newborns with amino acidemias (45.45%, 1:4176), 28 newborns with organic acidurias (36.36%, 1:5220), and 12 newborns and two mothers with FAO disorders (18.18%; 1:10439 or 1:12179 without mothers). Phenylketonuria and methylmalonic acidemia were the two most common disorders, accounting for 65.33% (49/75) of all confirmed newborn. Some hotspot mutations were observed for several IEMs, including PAH gene c.728G>A for phenylketonuria; MMACHC gene c.609G>A and c.567dupT, MMUT gene c.323G>A for methylmalonic acidemia and SLC25A13 gene c.852_855del for citrin deficiency. Our study provides effective clinical guidance for the popularization and application of expanded newborn screening, genetic screening, and genetic counseling of IEMs in this region.

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A new ‘seeding’ approach for the intercalation of protonated 1,10-phenanthroline into layered NiPS3 by using dopants as reaction active sites is proposed.

We theoretically study the phase sensitivity of an SU(1,1) interferometer with a thermal state and a squeezed vacuum state as inputs and parity detection as the measurement. We find that the phase sensitivity can beat the shot-noise limit and approaches the Heisenberg limit, with increasing input photon number, in an ideal situation. We also consider the effect of various noises, including photon loss, dark counts, and thermal photon noise. Our results show that the phase sensitivity is below the shot-noise limit with photon loss and dark counts, but cannot beat the shot-noise limit in the presence of thermal noise.