SignificanceThe variation of pitch in speech not only creates the intonation for affective communication but also signals different meaning of a word in tonal languages, like Chinese. Due to its subtle and brisk pitch contour distinction between tone categories, the underlying neural processing mechanism is largely unknown. Using direct recordings of the human brain, we found categorical neural responses to lexical tones over a distributed cooperative network that included not only the auditory areas in the temporal cortex but also motor areas in the frontal cortex. Strong causal links from the temporal cortex to the motor cortex were discovered, which provides new evidence of top-down influence and sensory–motor interaction during speech perception.

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Objective. By detecting abnormal white matter changes, diffusion magnetic resonance imaging (MRI) contributes to the detection of juvenile myoclonic epilepsy (JME). In addition, deep learning has greatly improved the detection performance of various brain disorders. However, there is almost no previous study effectively detecting JME by a deep learning approach with diffusion MRI. Approach. In this study, the white matter structural connectivity was generated by tracking the white matter fibers in detail based on Q-ball imaging and neurite orientation dispersion and density imaging. Four advanced deep convolutional neural networks (CNNs) were deployed by using the transfer learning approach, in which the transfer rate searching strategy was proposed to achieve the best detection performance. Main results. Our results showed: (a) Compared to normal control, the white matter’ neurite density of JME was significantly decreased. The most significantly abnormal fiber tracts between the two groups were found to be cortico-cortical connection tracts. (b) The proposed transfer rate searching approach contributed to find each CNN’s best performance, in which the best JME detection accuracy of 92.2% was achieved by using the Inception_resnet_v2 network with a 16% transfer rate. Significance. The results revealed: (a) Through detection of the abnormal white matter changes, the white matter structural connectivity can be used as a useful biomarker for detecting JME, which helps to characterize the pathophysiology of epilepsy. (b) The proposed transfer rate, as a new hyperparameter, promotes the CNNs transfer learning performance in detecting JME.