Hepatocyte apoptosis plays important roles in both the removal of external microorganisms and the occurrence and development of liver diseases. Different conditions, such as virus infection, fatty liver disease, hepatic ischemia reperfusion, and drug-induced liver injury, are accompanied by hepatocyte apoptosis. This review summarizes recent research on the mechanism of hepatocyte apoptosis involving the classical extrinsic and intrinsic apoptotic pathways, endoplasmic reticulum stress, and oxidative stress-induced apoptosis. We emphasized the major causes of apoptosis according to the characteristics of different liver diseases. Several concerns regarding future research and clinical application are also raised.

Esomeprazole administrated by infusion produces better pharmacokinetic and intragastric pH profiles compared with those by injection. The optimal administration schedule for esomeprazole in Chinese subjects is infusion with 40 mg/12 h.

Beshoy Morkos is an associate professor in the College of Engineering at the University of Georgia. His lab currently performs research in the areas of system design, manufacturing, and their respective education. His engineering design research focuses on developing computational representation and reasoning support for managing complex system design. The goal of Dr. Morkos' design research is to fundamentally reframe our understanding and utilization of system representations and computational reasoning capabilities to support the development of system models which help engineers and project planners intelligently make informed decisions at earlier stages of engineering design. On the engineering education front, Dr. Morkos' research explores means to enhance engineering education, improve persistence in engineering, and address challenges in senior design education. Dr. Morkos' research is