Background
This study aimed to assess the clinical efficacy of one-stage posterior surgery combined with anti-Brucella therapy in the treatment of lumbosacral brucellosis spondylitis (LBS).
Methods
From June 2010 to June 2020, the clinical and radiographic data of patients with LBS treated by one-stage posterior surgery combined with anti-Brucella therapy were retrospectively analyzed. The visual analogue scale (VAS), Japanese Orthopaedic Association (JOA) and Oswestry Disability Index scores (ODI) were used to evaluate the clinical outcomes. Frankel’s classification system was employed to access the initial and final neurologic function. Fusion of the bone grafting was classified by Bridwell’s grading system.
Results
A total of 55 patients were included in this study with a mean postoperative follow-up time of 2.6 ± 0.8 years (range, 2 to 5). There were 40 males and 15 females with a mean age of 39.8 ± 14.7 years (range, 27 to 57). The Brucella agglutination test was ≥ 1:160 in all patients, but the blood culture was positive in 43 patients (78.1%). A statistical difference was observed in ESR, CRP, VAS, ODI, and JOA between preoperative and final follow-up (P < 0.05). Neurological function was significantly improved in 20 patients with preoperative neurological dysfunction after surgery. According to Bridwell’s grading system, the fusion of bone grafting in 48 cases (87.2%) was defined as grade I, and grade II in 7 cases (12.7%). None of the infestation recurrences was observed.
Conclusion
One-stage posterior surgery combined with anti-Brucella therapy was a practical method in the treatment of LBS with severe neurological compression and spinal sagittal imbalance.
Background
This study aimed to assess the clinical efficacy of one-stage posterior surgery combined with anti-Brucella therapy in the treatment of lumbosacral brucellosis spondylitis (LBS).
Methods
From June 2010 to June 2020, the Clinical and radiographic data of patients with LBS treated by one-stage posterior surgery combined with anti-Brucella therapy were retrospectively analyzed. The Visual Analogue Scale (VAS), Oswestry Disability Index (ODI), Frankel classification system, Japanese Orthopaedic Association (JOA) scale, and Bridwell grading system were utilized to evaluate the results of preoperative and postoperative recovery.
Results
A total of 55 patients who met the criteria were included in this study with a mean postoperative follow-up time of 2.6 ± 0.8 years. There were 40 males and 15 females with a mean age of 39.8 ± 14.7 years. The preoperative Brucella agglutination test was ≥ 1: 160 in all patients, but the blood culture was positive in 43 patients (78.1%). ESR and CRP returned to normal at 3 postoperative months, and a statistical difference was observed between the preoperative vs. three postoperative months (P < 0.05), and the preoperative vs. final follow-up (P < 0.05). VAS, ODI, and JOA scores of the preoperative were improved after surgery, there was a statistical difference in the comparison with three postoperative months, and final follow-up (P < 0.05). The satisfactory recovery of lower limb motor function was received in 53 patients (96.3%) after surgery. None of the infestation recurrences was observed.
Conclusions
One-stage posterior surgery combined with anti-brucella therapy is a practical method in the treatment of LBS with severe neurological compression and spine sagittal imbalance.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.