The aim of this study was to summarize our experience of ovarian cancer diagnosed during pregnancy, to review the literature concerned, and to discuss the rationale for therapy. Twenty-two patients of ovarian malignancies complicating pregnancy were treated at Peking Union Medical College Hospital between 1985 and 2003. Data on treatment and follow-up were reviewed, and their outcomes were analyzed by survival analysis. The incidence of ovarian carcinoma complicating pregnancy in the series was 0.073/1000 pregnancies. Nine (40.9%) were found with ovarian malignant germ cell tumors, six (27.3%) with low malignant potential tumors, five (22.7%) with invasive epithelial tumors, and two (9.1%) with sex cord stromal tumors. Sixteen (72.7%) of the patients were diagnosed in stage I and had achieved complete remission. Four of the five in advanced stage died. Ascites presenting at diagnosis implies advanced disease and gloomy prognosis. The mean follow-up was 47.8 months. The prognosis was significantly related with stage and histologic type (P < 0.05). Thirteen healthy live babies were recorded in this group, and one premature newborn died of respiratory distress syndrome. The clinical characters and prognosis of ovarian cancers complicating pregnancy are similar to those of nonpregnant, reproductive-age women. Management depends on histology of the tumor, stage of the tumor, and the term of the pregnancy. In most of cases, conservative surgical treatment could be performed with adequate staging and debulking equal to the treatment of nonpregnant women. Chemotherapy is not contraindicated during the second or third trimester, but the choice of couple must be considered.

respectively. The disease stage and tumor differentiation subgroups showed significantly different detection sensitivities; the sensitivity was 10% in early-stage patients and 56% in advanced-stage patients (p = 0.0014). For patients with poorly differentiated tumors, the sensitivity was 77.8%, which was significantly different from those with highly differentiated (20%; p = 0.0230) and moderately differentiated tumors (19%; p = 0.0042). Conclusion: Blood analyses for EGFR mutations may be effectively used in advanced-stage patients or patients with poorly differentiated tumors.

No abstract

As one type of voluntary environmental regulations, environmental disclosure plays an important role in promoting sustainable development of enterprises by enhancing their environmental awareness. Based on the social responsibility and annual reports published by heavily polluting listed companies in China between 2007 and 2016, this article investigates their environmental disclosure and assesses the impact on their green innovation activities as well as its influence mechanisms. Text analysis is used to measure the environmental disclosure by way of three dimensions including environmental investment and management, environmental supervision and agency certification, and environmental performance and governance. The results of the Poisson regression model for panel data show that environmental disclosure has significantly encouraged green innovations carried out by heavily polluting listed companies in China during the past decade and this result is consistent with a variety of robustness checks. Besides, the mediation effect test demonstrates that environmental disclosure stimulated green innovations of heavily polluting listed companies by expanding their financing channels, promoting their product sales, and raising media attention.

No abstract

No abstract

Understanding the growth behaviour of an aluminosilicate sol during ageing is necessary for the design of the sol and the synthesis of NaY zeolite. Herein, aluminosilicate sols with three different SiO 2 /Al 2 O 3 ratios were prepared and aged for varying times at 293 K. The sol was then introduced as a structuredirecting agent in the feedstock gel to generate NaY zeolite. The structure evolution of the sol species during the ageing process was studied by in situ small-angle X-ray scattering (SAXS) using synchrotron radiation. SAXS data, in combination with transmission electron microscopy images, Raman spectra and X-ray diffraction patterns, present a detailed description of the sol species, revealing an interplay between the fractal structure and reactivity to generate NaY zeolite. The SiO 2 /Al 2 O 3 ratios in the sol play a critical role in the structure evolution of the aluminosilicate species during the ageing, particularly with respect to their size distributions and the fractal dimensions. The species with suitable size and compactness in the sol are found to be an active precursor for achieving a highly crystalline NaY zeolite. The sol with an SiO 2 /Al 2 O 3 ratio of 20 possesses active species with a mass fractal dimension D m of 2.0-2.6 after ageing, which leads to the formation of a well crystallized NaY zeolite. However, the high-silica sol-25, with an SiO 2 /Al 2 O 3 ratio of 25, and alumina rich sol-10, with a ratio of 10, experience growth at either slow or fast rates. In these cases the active species have smaller D m (1.1-1.9) or larger D m (2.6-2.8), respectively, displaying low/poor activity to generate NaY zeolite. The mechanisms regulating the growth behaviour of the sols during ageing are proposed.

We report a novel class of liquid crystalline (LC) nanohybrid ionogels fabricated via self-assembly of natural halloysite nanotubes (HNTs) in ionic liquids (ILs). The obtained ionogels are very stable and nonvolatile and show LC phases over a wide temperature range. Remarkably, the nanocomposite ionogels exhibit high anisotropic ionic conductivity after shear, and their room temperature ionic conductivity can reach 3.8 × 10(-3) S cm(-1) for aligned nanotubes perpendicular to the electrode even when the HNTs content increases to 40 wt%, which is 380 times higher than that obtained for aligned nanotubes parallel to the electrode, which is 1.0 × 10(-5) S cm(-1). Crucially, the obtained LC nanocomposite ionogels have very high thermal stability, which can sustain 400 °C thermal treatment. The findings will promote the development of novel nanocomposite ionogel electrolytes with faster ion transport and larger anisotropic conductivity.