Keywords: Synthetic methods / Asymmetric catalysis / Enantioselectivity / Nitrogen heterocycles / Alkylation 3,3Ј-Triphenylsilyl-substituted (S)-BINOL-based (1,1Ј-bi-2-naphthol) phosphoric acid has proven to be an effective organocatalyst for the asymmetric Friedel-Crafts alkylation of indoles with 3-substituted 3-hydroxyisoindolin-1-ones, affording the corresponding quaternary carbon-containing 3,3-disubstituted isoindolin-1-ones in good yields (up to 99 %)
Chiral phosphoric acids have been proven to be effective organocatalysts for the asymmetric Friedel-Crafts alkylation of indoles with 3-hydroxyisoindolin-1-ones. The corresponding products were obtained in excellent chemical yields (up to 99 %) with moderate to excellent enantioselectivities (up to
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