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Political trust can lead to cooperation and is very important in emergency and disaster management. However, the impact of disaster events on political trust is complicated. On May 12, 2008, a disruptive earthquake hit Southwest China, killing thousands of people and causing billions in economic losses. The Chinese national government's swift response was praised by the public, but the local government trust was not well documented. Through fieldwork in one of the most damaged counties, how disaster relief work affected the trust in local government was analyzed.Political trust varies in different levels of government in China. People trust the central government more than the local government. After the earthquake, there was a polarization trend in the local political trust. The few cases of role abandonment had a very bad effect on local political trust. The pre-disaster distrust, the impolite manners of local officials, and the gap between public expectations and the local government capacity in disaster relief impaired trust in local government. An easily operated and widely covered disaster assistance model is good to improve political trust after extreme tragedies. How to implement policies effectively and equally at the local level and the intergovernmental interchanges are the challenges for all levels of government, and will impact the public's trust in government.

The increased incidence of systemic lupus erythematosus (SLE) in recent decades might be related to changes in modern dietary habits. Since sodium chloride (NaCl) promotes pathogenic T cell responses, we hypothesize that excessive salt intake contributes to the increased incidence of autoimmune diseases, including SLE. Given the importance of dendritic cells (DCs) in the pathogenesis of SLE, we explored the influence of an excessive sodium chloride diet on DCs in a murine SLE model. We used an induced lupus model in which bone marrow-derived dendritic cells (BMDCs) were incubated with activated lymphocyte-derived DNA (ALD-DNA) and transferred into C57BL/6 recipient mice. We observed that a high-salt diet (HSD) markedly exacerbated lupus progression, which was accompanied by increased DC activation. NaCl treatment also stimulated the maturation, activation and antigen-presenting ability of DCs in vitro. Pretreatment of BMDCs with NaCl also exacerbated BMDC-ALD-DNA-induced lupus. These mice had increased production of autoantibodies and proinflammatory cytokines, more pronounced splenomegaly and lymphadenopathy, and enhanced pathological renal lesions. The p38 MAPK–STAT1 pathway played an important role in NaCl-induced DC immune activities. Taken together, our results demonstrate that HSD intake promotes immune activation of DCs through the p38 MAPK–STAT1 signaling pathway and exacerbates the features of SLE. Thus, changes in diet may provide a novel strategy for the prevention or amelioration of lupus or other autoimmune diseases.

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