Sensor applications in medical instrumentation measurement are very extensive, but mostly the input and output of the sensor is nonlinear, which brings a great inconvenience for the measure of medical instruments. This paper introduces biological immune system on the basis of the evolution planning, thereby forming immunization programs to use non-linear calibration of the sensor. This method joins nonlinear correction links after sensor amplification and A/D converter links and uses the immunization program to obtain the polynomial coefficients of the nonlinear correction link. Simulations show that using immunization programs to have non-linear calibration to sensor, gives high correction accuracy, faster convergence speed and very good stability.
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