Abstract. Audio feature extraction is a very important technique in the field of sound processing. It extremely impacts the effectiveness and correctness of sound recognition, sound verification, etc. It is a computation intensive stage in the whole sound recognition process, which is a challenging for acceleration. In this paper, a coarse-grained parallel feature extraction algorithm for high throughput of audio slices is proposed to improve the efficiency of audio feature extraction. Three typical audio feature extraction algorithms, Mel Frequency Cepstrum Coefficients(MFCC), Spectrogram image features(SIF), Octave-Based Spectral Contrast, are chosen to parallelize. Experiments results on different platforms show that the speedup of accelerated audio feature extraction is up to 17.23 on the platform with 16 cores 32 threads.
Objective
Microscopy was used to characterize platelet-
Plasmodium
-infected erythrocyte interactions in patients infected with
Plasmodium falciparum
,
Plasmodium vivax
,
Plasmodium ovale
or
Plasmodium malariae
, and to investigate the relationship between platelet-associated parasite killing and parasite clearance.
Methods
Data from 244 malaria patients admitted to the Fourth People’s Hospital of Nanning between 1 January 2011 and 30 September 2022, and 45 healthy controls, were collected prospectively and assessed retrospectively. Characteristics of platelet–erythrocyte interactions were visualized by microscopy, and blood cell count and clinical profiles of these participants were obtained from the electronic medical records. ANOVA, contingency tables and Cox proportional hazards regression models were used to do statistical analysis on the subgroups.
Results
Platelet enlargement and minor pseudopodia development were observed. Platelets were found directly attaching to parasitized erythrocytes by all
Plasmodium
species studied, especially mature stages, and lysis of parasitized erythrocytes was connected to platelet-mediated cytolysis. Platelet counts were correlated inversely with parasitaemia and duration of parasite clearance. Artemisinin combination therapy was more effective than artemisinin alone in clearing
Plasmodium
in patients with thrombocytopenia.
Conclusions
Platelet-parasitized erythrocytes cell-to-cell contacts initiated platelet-associated parasite killing and helped to limit
Plasmodium
infection in cases of human malaria. The weakening platelet-associated parasite killing effects could be counteracted by artemisinin combination therapy in patients with thrombocytopenia.
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