Rad51c is critical for homologous recombination repair and genomic stability and may play roles in tumorigenesis and cancer therapy. We investigated the expression level and clinical significance of Rad51c in non-small cell lung cancer (NSCLC) and determined the effect of Rad51c on NSCLC cell chemosensitivity and radiosensitivity. Rad51c expression was detected using immunohistochemistry and was higher in NSCLC patient samples than in adjacent normal tissues. Kaplan-Meier analysis revealed that high Rad51c expression was an independent predictor of short overall survival (OS) and disease-free survival (DFS) in NSCLC patients receiving chemotherapy and/or radiotherapy. Furthermore, Rad51c knockdown increased the killing effect of ionizing radiation (IR) and enhanced cisplatin-induced apoptotic cells in NSCLC cells by disrupting the repair of cisplatin- and IR-induced DNA damage. In addition, ectopic expression of Rad51c dramatically enhanced NSCLC cell resistance to cisplatin and radiotherapy. These findings suggest that increased expression of Rad51c may confer resistance to chemotherapy and/or radiotherapy of NSCLC, and also be an independent prognostic factor for patient outcome. Therefore, targeting Rad51c may represent an improved therapeutic strategy for NSCLC patients with locally advanced disease.
To effectively reject the gyroscopic effects and moving-gimbal effects of the double gimbal magnetically suspended control moment gyroscope (DGMSCMG) and to avoid high control effort, this paper proposes a novel control method based on modal decoupling strategy. Modal controller is employed to realize the modal separation of the translation and rotation modes of the magnetically suspended rotor (MSR). Then the dynamic coupling among the two rotation modes of the MSR system and the two rotational motions of the gimbal servo systems have been decoupled by using differential geometry theory. Dynamic compensation filters have been designed to improve the decoupling performance and the system stability without large control resource. Compared with the existing channel decoupling method, the presented one can not only realize the separate control of stiffness and damping of the MSR but also simplify the control system design significantly. The simulation results verify the effectiveness and superiority of the proposed method.
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