No abstract

Vagus nerve stimulation (VNS) has been shown to improve left ventricular function and survival in rats with acute myocardial infarction (AMI), and this maneuver has also been adopted clinically for the treatment of patients with chronic heart failure (CHF). Recent in vitro and in vivo studies have suggested that VNS can modulate the level of pro-inflammatory factors. Despite the beneficial effects of VNS, the stimulation parameters for obtaining favorable outcomes appear highly variable. To optimize VNS parameters, we set up different stimulation protocols with different pulse width (1–2 ms), frequency (1–6 Hz), voltage (1–6 V) and duration (40–240 min) of VNS by uniform design (UD). Rats were divided into seven groups with (Group1–Group6) or without VNS (MI group). Our results demonstrate that (1) the parameter sets in Group1, Group2 and Group3 yield the best post-MI protection by VNS, while the protective role were not observed in Group4, Group5 and Group6; (2) baroreflex sensitivity and the α7 nicotinic acetylcholine receptor level were also increased in Group1, Group2 and Group3. (3) the parameter set in Group1 (G1:1 ms, 2 Hz, 3 V, 240 min) is judged the most optimal parameter in this study as rats in this group not only showed a reduced myocardial injury with better-preserved cardiac function compared with other groups, more important, but also exhibited minimal heart rate (HR) reduction. (4) the duration of VNS plays an important role in determining the protection effect of VNS. In conclusion, VNS displays a beneficial role in Group1, Group2 and Group3. Of note, the parameter set in Group1 provides the most optimal cardioprotective effect. These results may provide insight into development of novel treatment for ischemic heart diseases.

Smart contracts are automated or self-enforcing contracts that can be used to exchange assets without having to place trust in third parties. Many commercial transactions use smart contracts due to their potential benefits in terms of secure peer-to-peer transactions independent of external parties. Experience shows that many commonly used smart contracts are vulnerable to serious malicious attacks, which may enable attackers to steal valuable assets of involving parties. There is, therefore, a need to apply analysis and automated repair techniques to detect and repair bugs in smart contracts before being deployed. In this work, we present the first general-purpose automated smart contract repair approach that is also gas-aware. Our repair method is search-based and searches among mutations of the buggy contract. Our method also considers the gas usage of the candidate patches by leveraging our novel notion of gas dominance relationship . We have made our smart contract repair tool SCRepair available open-source, for investigation by the wider community.

Along with an unexpected conducting interface between nonmagnetic insulating perovskites LaAlO and SrTiO (LaAlO/SrTiO), striking interfacial magnetisms have been observed in LaAlO/SrTiO heterostructures. Interestingly, the strength of the interfacial magnetic moment is found to be dependent on oxygen partial pressures during the growth process. This raises an important, fundamental question on the origin of these remarkable interfacial magnetic orderings. Here, we report a direct evidence of room-temperature stable magnetism in a LaAlO/SrTiO heterostructure prepared at high oxygen partial pressure by using element-specific soft X-ray magnetic circular dichroism at both Ti L and O K edges. By combining X-ray absorption spectroscopy at both Ti L and O K edges and first-principles calculations, we qualitatively ascribe that this strong magnetic ordering with dominant interfacial Ti character is due to the coexistence of LaAlO surface oxygen vacancies and interfacial (Ti-Al) antisite defects. On the basis of this new understanding, we revisit the origin of the weak magnetism in LaAlO/SrTiO heterostructures prepared at low oxygen partial pressures. Our calculations show that LaAlO surface oxygen vacancies are responsible for the weak magnetism at the interface. Our result provides direct evidence on the presence of room-temperature stable magnetism and a novel perspective to understand magnetic and electronic reconstructions at such strategic oxide interfaces.