This paper introduces , a fast deformable image registration method. registration for image-pairs works by patch-wise prediction of a deformation model based directly on image appearance. A deep encoder-decoder network is used as the prediction model. While the prediction strategy is general, we focus on predictions for the Large Deformation Diffeomorphic Metric Mapping (LDDMM) model. Specifically, we predict the momentum-parameterization of LDDMM, which facilitates a patch-wise prediction strategy while maintaining the theoretical properties of LDDMM, such as guaranteed diffeomorphic mappings for sufficiently strong regularization. We also provide a probabilistic version of our prediction network which can be sampled during the testing time to calculate uncertainties in the predicted deformations. Finally, we introduce a new correction network which greatly increases the prediction accuracy of an already existing prediction network. We show experimental results for uni-modal atlas-to-image as well as uni-/multimodal image-to-image registrations. These experiments demonstrate that our method accurately predicts registrations obtained by numerical optimization, is very fast, achieves state-of-the-art registration results on four standard validation datasets, and can jointly learn an image similarity measure. is freely available as an open-source software.

Computed tomography (CT) is the preferred imaging method for diagnosing 2019 novel coronavirus (COVID19) pneumonia. We aimed to construct a system based on deep learning for detecting COVID-19 pneumonia on high resolution CT. For model development and validation, 46,096 anonymous images from 106 admitted patients, including 51 patients of laboratory confirmed COVID-19 pneumonia and 55 control patients of other diseases in Renmin Hospital of Wuhan University were retrospectively collected. Twenty-seven prospective consecutive patients in Renmin Hospital of Wuhan University were collected to evaluate the efficiency of radiologists against 2019-CoV pneumonia with that of the model. An external test was conducted in Qianjiang Central Hospital to estimate the system’s robustness. The model achieved a per-patient accuracy of 95.24% and a per-image accuracy of 98.85% in internal retrospective dataset. For 27 internal prospective patients, the system achieved a comparable performance to that of expert radiologist. In external dataset, it achieved an accuracy of 96%. With the assistance of the model, the reading time of radiologists was greatly decreased by 65%. The deep learning model showed a comparable performance with expert radiologist, and greatly improved the efficiency of radiologists in clinical practice.

We present a robust end-to-end neural-based model to attentively recognize text in natural images. Particularly, we focus on accurately identifying irregular (perspectively distorted or curved) text, which has not been well addressed in the previous literature. Previous research on text reading often works with regular (horizontal and frontal) text and does not adequately generalize to processing text with perspective distortion or curving effects. Our work proposes to overcome this difficulty by introducing two learning components: (1) an auxiliary dense character detection task that helps to learn text specific visual patterns, (2) an alignment loss that provides guidance to the training of an attention model. We show with experiments that these two components are crucial for achieving fast convergence and high classification accuracy for irregular text recognition. Our model outperforms previous work on two irregular-text datasets: SVT-Perspective and CUTE80, and is also highly-competitive on several regular-text datasets containing primarily horizontal and frontal text.

The Soil Moisture Active Passive (SMAP) mission has delivered valuable sensing of surface soil moisture since 2015. However, it has a short time span and irregular revisit schedules. Utilizing a state-of-the-art time series deep learning neural network, Long Short-Term Memory (LSTM), we created a system that predicts SMAP level-3 moisture product with atmospheric forcings, model-simulated moisture, and static physiographic attributes as inputs. The system removes most of the bias with model simulations and improves predicted moisture climatology, achieving small test root-mean-square errors (<0.035) and high-correlation coefficients >0.87 for over 75% of Continental United States, including the forested southeast. As the first application of LSTM in hydrology, we show the proposed network avoids overfitting and is robust for both temporal and spatial extrapolation tests. LSTM generalizes well across regions with distinct climates and environmental settings. With high fidelity to SMAP, LSTM shows great potential for hindcasting, data assimilation, and weather forecasting. Plain Language Summary Soil moisture is the water content in soil, and it is a critical component of the water cycle. It controls whether crops or wild vegetation can function properly, the risk of wildfire, and the likelihood of floods. The NASA satellite SMAP, launched in 2015, measures soil moisture near the ground surface over Earth at high accuracy. SMAP data are of great value to global communities to which soil moisture is relevant. However, since it was launched only recently, there is only little overlap with other data sets, which limits its use. To extend SMAP's observations in time, we employ a "deep learning" technology called Long Short-Term Memory (LSTM), which is one of the pillars of artificial intelligence and is bringing revolutionary changes in many scientific fields and our daily lives. We use LSTM to learn patterns of soil moisture dynamics and where physics-based models make mistakes in describing moisture changes. This approach shows great promise for projecting SMAP observations into the long past: because soil moisture has a short memory, 2 years of data seem sufficient to train LSTM to successfully capture its dynamics. Because LSTM can handle large and diverse data, it offers valuable alternatives to older statistical methods.

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Abstract. We present a method to predict image deformations based on patch-wise image appearance. Specifically, we design a patch-based deep encoder-decoder network which learns the pixel/voxel-wise mapping between image appearance and registration parameters. Our approach can predict general deformation parameterizations, however, we focus on the large deformation diffeomorphic metric mapping (LDDMM) registration model. By predicting the LDDMM momentum-parameterization we retain the desirable theoretical properties of LDDMM, while reducing computation time by orders of magnitude: combined with patch pruning, we achieve a 1500x/66x speed up compared to GPU-based optimization for 2D/3D image registration. Our approach has better prediction accuracy than predicting deformation or velocity fields and results in diffeomorphic transformations. Additionally, we create a Bayesian probabilistic version of our network, which allows evaluation of deformation field uncertainty through Monte Carlo sampling using dropout at test time. We show that deformation uncertainty highlights areas of ambiguous deformations. We test our method on the OASIS brain image dataset in 2D and 3D.

Background: NMDA receptor and Na ϩ /Ca 2ϩ exchanger are involved in glutamate-induced calcium dysregulation in neurons. Results: CRMP2 interacts with and modulates activity of the NMDA receptor and Na ϩ /Ca 2ϩ exchanger. Conclusion: CRMP2 is involved in regulation of Ca 2ϩ homeostasis in neurons exposed to glutamate. Significance: CRMP2 interaction with NMDA receptor and Na ϩ /Ca 2ϩ exchanger affects their activity and is important for glutamate-induced Ca 2ϩ dysregulation.

We prepared 13 derivatives of N-(biphenyl-4′-yl)methyl (R)-2-acetamido-3-methoxypropionamide that differed in type and placement of a R-substituent in the terminal aryl unit. We demonstrated that the R-substituent impacted the compound’s whole animal and cellular pharmacological activities. In rodents, select compounds exhibited excellent anticonvulsant activities and protective indices (PI = TD50/ED50) that compared favorably with clinical antiseizure drugs. Compounds with a polar, aprotic R-substituent potently promoted Na+ channel slow inactivation and displayed frequency (use) inhibition of Na+ currents at low micromolar concentrations. The possible advantage of affecting these two pathways to decrease neurological hyperexcitability is discussed.