This study was conducted to investigate the application of the antagonistic yeast strain ofHanseniaspora uvarumcombined with salicylic acid (SA) and sodium bicarbonate (SBC) to create an efficient integrated approach to control grey mould on grapes. The results indicated that the treatment of 1×108CFU/mlH. uvarumcombined with SA at 2 mM and combined with SBC at 2% resulted in a remarkably improved control ofB. cinereainfections on grapes at 25°C,RH 95%. In experimental trials, the average lesion diameter of the samples treated withH.uvarumplus 2 mM SA andH. uvarumplus 2% SBC after 3 days were both 0.81 cm, which were significantly smaller compared with that of the samples treated withH. uvarumindividually (0.891 cm; 0.9 cm) and with sterile distilled water (1.318 cm; 1.36 cm). Furthermore, integration ofH. uvarumwith SA and with SBC both significantly reduced the decay rate, leave rate, weight loss while maintained the firmness, titratable acidity (TA), total soluble solids (TSS) of the grapes. The proper combination of antagonist yeasts and chemical reagent can thus provide an effective strategy to reduce postharvest decay of grape fruit.
Key Clinical MessageWe report an extremely rare case of acute myelomonocytic leukemia (M4) with an MLL-ELL fusion gene lacking the PML-RARα rearrangement that transformed from hypergranular acute promyelocytic leukemia (APL) without showing any karyotypic evolution. The treatment was effective with chemotherapy for M4 and idarubicin plus a cytarabine-based chemotherapy protocol without ATRA.
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