Titanium alloys, such as Ti-10Ta-2Nb-2Zr (TTNZ), are promising biomaterials due to their excellent biocompatibility and low Young’s modulus. The TTNZ samples herein were manufactured by selective laser melting and the novel material was evaluated as a dental implant in vitro and in vivo. The microstructure, mechanical properties, electrochemical behaviour, cytotoxicity, haemocompatibility and osteogenic differentiation were systematically investigated. Based on the tensile test results, the as-printed TTNZ samples had an elongation of 20.23% ± 1.95%, an ultimate tensile strength of 646.61 ± 24.96 MPa and a Young’s modulus of 23.72 ± 1.18 GPa. According to the biocompatible value, the as-printed TTNZ sample exhibited no cell cytotoxicity and it showed even better cell adhesion ability than that of the as-printed Ti-6Al-4 V and wrought Ti-6Al-4 V samples. The haemolysis percentage of the as-printed TTNZ sample was 0.629% ± 0.363%. Moreover, the as-printed TTNZ sample facilitated protein adsorption and osteogenic differentiation of human osteoblast-like (MG-63) cells in vitro. The in vivo data also demonstrated the histocompatibility of the as-printed TTNZ. In summary, the as-printed TTNZ developed in this study demonstrated good biocompatibility, low stress shielding, excellent ductility and great osteogenic differentiation. These results indicated that as-printed TTNZ alloys can be promising for end-use human biomedical applications.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.