In this work, a novel mesoporous luminescence-functionalized metal-organic framework (Ru-PCN-777) with high stability and excellent electrochemiluminescence (ECL) performance was synthesized by immobilizing Ru(bpy)(mcpbpy) on the Zr cluster of PCN-777 via a strong coordination bond between Zr and -COO. Consequently, the Ru(bpy)(mcpbpy) could not only cover the surface of PCN-777 but also graft into the interior of PCN-777, which greatly increased the loading amount of Ru(bpy)(mcpbpy) and effectively prevented the leaching of the Ru(bpy)(mcpbpy) resulting in a stable and high ECL response. Considering the above merits, we utilized the mesoporous Ru-PCN-777 to construct an ECL immunosensor to detect mucin 1 (MUC1) based on proximity-induced intramolecular DNA strand displacement (PiDSD). The ECL signal was further enhanced by the enzyme-assisted DNA recycling amplification strategy. As expected, the immunosensor had excellent sensitivity, specificity, and responded wide linearly to the concentration of MUC1 from 100 fg/mL to 100 ng/mL with a low detection limit of 33.3 fg/mL (S/N = 3). It is the first time that mesoporous Zr-MOF was introduced into ECL system to assay biomolecules, which might expand the application of mesoporous metal-organic frameworks (MOFs) in bioanalysis. This work indicates that the use of highly stable mesoporous luminescence-functionalized MOFs to enhance the ECL intensity and stability is a feasible strategy for designing and constructing high-performance ECL materials, and therefore may shed light on new ways to develop highly sensitive and selective ECL sensors.

N atoms were selectively doped at substitutional or interstitial sites in the MnO2 lattice using N2 plasma. This research provides a site-selective N-doping method and a deep insight into the different effects of doping sites.

Four porous interpenetrated fluorescent MOFs based on π-electron-rich N-donor ligands can effectively detect nitroaromatic explosives and exhibit highly sensitive responses to 2,4,6-trinitrophenol.

Four photochromic MOFs show that electron-withdrawing capabilities of metal ions play a significant role in tuning the photosensitivity of photochromic MOFs.