Sarcandra glabra THUMB. NAKAI (Chloranthus glaber THUNB. MAKINO), distributed mainly in the south of Asia, was widely used as an antibacterial and antitumor herb in China.
1)Previous phytochemical studies indicated that sesquiterpenes were characteristic constituents for S. glabra.2-4) Our interest in identification of sesquiterpene constituents prompted us to conduct a detailed chemical investigation into the S. glabra. In our research, two new lindenane sesquiterpene glycosides 1, 2 and a new eudesmanolide sesquiterpene glycoside 3, together with five known sesquiterpenes and sesquiterpene glycosides (4-8), have been isolated and structurally characterized.The 95% EtOH extract of the whole plant of S. glabra afforded three new compounds named sarcaglabosides F-H. Their structures were established by means of spectroscopic and chemical methods as 8b,9b-epoxy-4a-hydroxy-5aH-lindan-7(11)-en-8a,12-olide-15-O-b-D-glucopyranoside (1), 4a-hydroxy-5a,8bH-lindan-7(11)-en-8a,12-olide-15-O-b-Dglucopyranoside (2) and 4a-hydroxy-5a,8bH-eudesman-7(11)-en-8a,12-olide-15-O-b-D-glucopyranoside (3), respectively. The five known compounds were subsequently identified as chloranoside A (4),6) 9-hydroxy-heterogorgiolide (7) 7) and chloranthalactone B (8) 2) by comparison of their spectral data (UV, IR, NMR and MS) with those reported previously. Compounds 6 and 7 were isolated from S. glabra for the first time.Compound 1 was obtained as a white amorphous powder. HR-ESI-MS and ESI-MS of 1 gave a molecular ion peak at m/z 463.1575 [MϩNa] ϩ and a quasimolecular ion peak at m/z 463 [MϩNa] ϩ in the positive-ion mode, respectively. In conjunction with the analysis of
Abstract:From the whole plant of Sarcandra glabra, a new phenolic acid glycoside, benzyl 2-β-glucopyranosyloxybenzoate (1), together with seven known compounds including eleutheroside B 1 (2), 5-O-caffeoylshikimic acid (3), (-)-(7S, 8R)-dihydrodehydrodiconiferyl alcohol (4), (-)-(7S, 8R)-dihydrodehydrodiconiferyl alcohol 9-, 9′-and 4-O-â-D-glucopyranoside (5-7), and (-)-(7S, 8R)-5-methoxydihydrodehydrodiconiferyl alcohol 4-O-β-D-glucopyranoside (8) was isolated. Their structures were elucidated by spectral analysis including 1D-, 2D-NMR and HR-ESI-MS. Compound 2 was found to exhibit potent cytotoxic activity against BGC-823 and A2780 cancer cell lines using MTT method with IC 50 value of 2.53 and 1.85 µM, respectively.
A new eudesmanolide sesquiterpene, atractylenolide IV (1), together with seven known compounds were isolated from the 70% aqueous acetonic extract of the whole plant of Sarcandra glabra (Chloranthaceae). Their structures were established by spectral analysis, mainly UV, IR, HRESI-MS, 1D and 2D-NMR experiments (HSQC, HMBC and NOESY). Compounds 1-4 showed no remarkable cytotoxic activity against Hela, HCT-8 and MCF-7 cancer cell lines with IC50 > 50 µg mL(-1).
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