As one of the most versatile intermediate group in synthetic chemistry, the introduction of an aldehyde group into a specific moiety is important for the transformation of molecular structures. Herein, we provided a metal-free, regioselective and one-pot formylation of the indolo[2,1a]isoquinoline moiety. This strategy features an oxidative coupling process using commercially available 1,3-dioxolane as a formylated reagent followed by direct hydrolyzation without a separation process. This reaction can be carried out under common reaction conditions and displays broad functional group tolerance.
scite is a Brooklyn-based organization that helps researchers better discover and understand research articles through Smart Citations–citations that display the context of the citation and describe whether the article provides supporting or contrasting evidence. scite is used by students and researchers from around the world and is funded in part by the National Science Foundation and the National Institute on Drug Abuse of the National Institutes of Health.